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Broad Promotes Neuroepithelial Stem Cell Differentiation in the Drosophila Optic Lobe.
GENETICS ( IF 3.3 ) Pub Date : 2019-11-1 , DOI: 10.1534/genetics.119.302421
Yanna Zhou 1 , Yuqin Yang 2 , Yanyi Huang 2 , Hui Wang 2 , Shengyu Wang 2 , Hong Luo 2, 3
Affiliation  

Brain development requires the generation of the right number, and type, of neurons and glial cells at the right time. The Drosophila optic lobe, like mammalian brains, develops from simple neuroepithelia; they first divide symmetrically to expand the progenitor pool and then differentiate into neuroblasts, which divide asymmetrically to generate neurons and glial cells. Here, we investigate the mechanisms that control neuroepithelial growth and differentiation in the optic lobe. We find that the Broad/Tramtrack/Bric a brac-zinc finger protein Broad, which is dynamically expressed in the optic lobe neuroepithelia, promotes the transition of neuroepithelial cells to medulla neuroblasts. Loss of Broad function causes neuroepithelial cells to remain highly proliferative and delays neuroepithelial cell differentiation into neuroblasts, which leads to defective lamina and medulla. Conversely, Broad overexpression induces neuroepithelial cells to prematurely transform into medulla neuroblasts. We find that the ecdysone receptor is required for neuroepithelial maintenance and growth, and that Broad expression in neuroepithelial cells is repressed by the ecdysone receptor. Our studies identify Broad as an important cell-intrinsic transcription factor that promotes the neuroepithelial-cell-to-neuroblast transition.

中文翻译:

Broad 促进果蝇视叶神经上皮干细胞分化。

大脑发育需要在正确的时间产生正确数量和类型的神经元和神经胶质细胞。果蝇视叶,像哺乳动物的大脑一样,由简单的神经上皮发育而来。它们首先对称分裂以扩大祖细胞库,然后分化成神经母细胞,神经母细胞不对称分裂产生神经元和神经胶质细胞。在这里,我们研究控制视叶神经上皮生长和分化的机制。我们发现Broad/Tramtrack/Bric a brac-锌指蛋白Broad在视神经上皮细胞中动态表达,促进神经上皮细胞向髓质神经母细胞的转变。广泛功能的丧失导致神经上皮细胞保持高度增殖并延迟神经上皮细胞分化为神经母细胞,从而导致椎板和髓质有缺陷。相反,广泛的过度表达会诱导神经上皮细胞过早转化为髓质神经母细胞。我们发现蜕皮激素受体是神经上皮维持和生长所必需的,并且神经上皮细胞中的广泛表达被蜕皮激素受体抑制。我们的研究发现 Broad 是一种重要的细胞内在转录因子,可促进神经上皮细胞向神经母细胞的转变。
更新日期:2021-05-08
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