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Diagnostic accuracy of flat-panel computed tomography in assessing cerebral perfusion in comparison with perfusion computed tomography and perfusion magnetic resonance: a systematic review.
Neuroradiology ( IF 2.8 ) Pub Date : 2019-09-16 , DOI: 10.1007/s00234-019-02285-y
Ernst L Stille 1 , Ilaria Viozzi 2 , Mark Ter Laan 2 , Frederick J A Meijer 1 , Jurgen J Futterer 1 , Maroeska M Rovers 3
Affiliation  

PURPOSE Flat-panel computed tomography (FP-CT) is increasingly available in angiographic rooms and hybrid OR's. Considering its easy access, cerebral imaging using FP-CT is an appealing modality for intra-procedural applications. The purpose of this systematic review is to assess the diagnostic accuracy of FP-CT compared with perfusion computed tomography (CTP) and perfusion magnetic resonance (MRP) in cerebral perfusion imaging. METHODS We performed a systematic literature search in the Cochrane Library, MEDLINE, Embase, and Web of Science up to June 2019 for studies directly comparing FP-CT with either CTP or MRP in vivo. Methodological quality was assessed using the QUADAS-2 tool. Data on diagnostic accuracy was extracted and pooled if possible. RESULTS We found 11 studies comparing FP-CT with CTP and 5 studies comparing FP-CT with MRP. Most articles were pilot or feasibility studies, focusing on scanning and contrast protocols. All patients studied showed signs of cerebrovascular disease. Half of the studies were animal trials. Quality assessment showed unclear to high risks of bias and low concerns regarding applicability. Five studies reported on diagnostic accuracy; FP-CT shows good sensitivity (range 0.84-1.00) and moderate specificity (range 0.63-0.88) in detecting cerebral blood volume (CBV) lesions. CONCLUSIONS Even though FP-CT provides similar CBV values and reconstructed blood volume maps as CTP in cerebrovascular disease, additional studies are required in order to reliably compare its diagnostic accuracy with cerebral perfusion imaging.

中文翻译:

平板计算机断层扫描在评估脑灌注方面与诊断计算机断层扫描和灌注磁共振相比的诊断准确性:系统评价。

目的平板计算机断层扫描(FP-CT)越来越多地用于血管造影室和混合型OR。考虑到其易于访问,使用FP-CT进行脑部成像是过程内应用的一种吸引人的方式。本系统综述的目的是评估FP-CT在脑灌注成像中与灌注计算机断层扫描(CTP)和灌注磁共振(MRP)相比的诊断准确性。方法截至2019年6月,我们在Cochrane图书馆,MEDLINE,Embase和Web of Science中进行了系统的文献检索,以直接比较FP-CT与CTP或MRP的体内研究。使用QUADAS-2工具评估方法学质量。如果可能,提取并合并有关诊断准确性的数据。结果我们发现11项比较FP-CT和CTP的研究和5项比较FP-CT和MRP的研究。大多数文章是试点或可行性研究,重点是扫描和对比协议。所有研究的患者均显示出脑血管疾病的体征。一半的研究是动物试验。质量评估表明存在偏见的高风险和对适用性的低关注尚不清楚。五项研究报告了诊断准确性;FP-CT在检测脑血容量(CBV)病变中显示出良好的灵敏度(范围为0.84-1.00)和中等的特异性(范围为0.63-0.88)。结论尽管FP-CT在脑血管疾病中提供了与CTP相似的CBV值和重建的血容量图,但仍需要进行其他研究才能可靠地将其诊断准确性与脑灌注成像进行比较。所有研究的患者均显示出脑血管疾病的体征。一半的研究是动物试验。质量评估表明存在偏见的高风险和对适用性的低关注尚不清楚。五项研究报告了诊断准确性;FP-CT在检测脑血容量(CBV)病变中显示出良好的灵敏度(范围为0.84-1.00)和中等的特异性(范围为0.63-0.88)。结论尽管FP-CT在脑血管疾病中提供了与CTP相似的CBV值和重建的血容量图,但仍需要进行其他研究才能可靠地将其诊断准确性与脑灌注成像进行比较。所有研究的患者均显示出脑血管疾病的体征。一半的研究是动物试验。质量评估表明存在偏见的高风险和对适用性的低关注尚不清楚。五项研究报告了诊断准确性;FP-CT在检测脑血容量(CBV)病变方面显示出良好的灵敏度(范围为0.84-1.00)和中等的特异性(范围为0.63-0.88)。结论尽管FP-CT在脑血管疾病中提供了与CTP相似的CBV值和重建的血容量图,但仍需要进行其他研究才能可靠地将其诊断准确性与脑灌注成像进行比较。FP-CT在检测脑血容量(CBV)病变方面显示出良好的灵敏度(范围为0.84-1.00)和中等的特异性(范围为0.63-0.88)。结论尽管FP-CT在脑血管疾病中提供了与CTP相似的CBV值和重建的血容量图,但仍需要进行其他研究才能可靠地将其诊断准确性与脑灌注成像进行比较。FP-CT在检测脑血容量(CBV)病变方面显示出良好的灵敏度(范围为0.84-1.00)和中等的特异性(范围为0.63-0.88)。结论尽管FP-CT在脑血管疾病中提供了与CTP相似的CBV值和重建的血容量图,但仍需要进行其他研究才能可靠地将其诊断准确性与脑灌注成像进行比较。
更新日期:2019-09-16
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