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Cognition and Cognitive Impairment in Migraine.
Current Pain and Headache Reports ( IF 3.7 ) Pub Date : 2019-09-11 , DOI: 10.1007/s11916-019-0824-7
Raquel Gil-Gouveia 1, 2 , Isabel Pavão Martins 2, 3
Affiliation  

Background

Migraine is a complex neurological disorder that affects a significant percentage of the human species, from all geographic areas and cultures. Cognitive symptoms and dysfunctions are interim and disabling components of this disorder and may be related to the brain processes underlying the pathophysiology. Yet they are often undervalued by clinicians. In this review, we present the different types of cognitive dysfunctions associated with migraine and the mechanisms that are potentially causing them.

Findings

While reversible attack-related cognitive dysfunction seems extremely consistent and likely related to functional cortical and subcortical brain changes occurring during attacks, interictal cognitive dysfunction is less consistent and might become more relevant as attack frequency and disease complexity increase. Migraine traits do not seem a predisposition to long-term cognitive decline.

Summary

Cognitive dysfunction is a frequent manifestation of migraine attacks and may be specific to this disorder; it is important to understand if it could be useful in migraine diagnosis. Attack-related cognitive dysfunction is clinically relevant and contributes to disability, so it should be perceived as a therapeutic target. While there is no evidence to support that migraine increases the risk of long-term or persistent cognitive dysfunction, the fact that it occurs during the attacks and may persist in subjects with frequent or complicated attacks should prompt the understanding of the mechanisms related to its pathophysiology for it may also clarify the processes underlying migraine.


中文翻译:

偏头痛的认知和认知障碍。

背景

偏头痛是一种复杂的神经系统疾病,会影响所有地理区域和文化的很大一部分人类。认知症状和功能障碍是该疾病的暂时性和致残性成分,可能与病理生理基础的大脑过程有关。然而,它们经常被临床医生低估。在这篇综述中,我们介绍了与偏头痛相关的不同类型的认知功能障碍以及可能导致它们的机制。

发现

尽管可逆的与发作有关的认知功能障碍似乎极为一致,并可能与发作期间发生的功能性皮质和皮质下大脑变化有关,但发作间期认知功能障碍的一致性较差,并且随着发作频率和疾病复杂性的增加而变得更加相关。偏头痛特征似乎不是长期认知能力下降的诱因。

概要

认知功能障碍是偏头痛发作的常见表现,可能是这种疾病特有的。重要的是要了解它是否对偏头痛诊断有用。与发作有关的认知功能障碍在临床上是相关的,并且会导致残疾,因此应将其视为治疗目标。尽管没有证据支持偏头痛会增加长期或持续性认知功能障碍的风险,但在发作过程中会发生偏头痛并可能在频繁发作或复杂发作的受试者中持续存在这一事实,应促使人们了解与其病理生理学相关的机制因为它也可能阐明偏头痛的过程。
更新日期:2019-09-11
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