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Pharmacokinetics of thymoquinone in layer chickens following oral and intravenous administration.
Journal of Veterinary Pharmacology and Therapeutics ( IF 1.3 ) Pub Date : 2019-09-06 , DOI: 10.1111/jvp.12810 Sehrish Iqbal 1 , Aqeel Javeed 1 , Adeel Sattar 1 , Rabia Tanvir 2
Journal of Veterinary Pharmacology and Therapeutics ( IF 1.3 ) Pub Date : 2019-09-06 , DOI: 10.1111/jvp.12810 Sehrish Iqbal 1 , Aqeel Javeed 1 , Adeel Sattar 1 , Rabia Tanvir 2
Affiliation
Thymoquinone (TQ) is the major constituent of Nigella sativa and known to possess a variety of pharmacological effects. This study was designed to evaluate the pharmacokinetic profile of TQ following oral (PO) and intravenous (IV) administration in layer chickens. The layer chickens were equally divided into two groups (six chickens in each group, total 12 chickens), and TQ was administered via PO and IV routes. For PO route, the dose was 20 mg/kg b.w. and for IV route, 5 mg/kg b.w. was administered, respectively. A sensitive and accurate High-Performance Liquid Chromatography (HPLC) technique was validated for the quantification of TQ from plasma. The limit of detection (LOD) and limit of quantification (LOQ) were 0.02 µg/ml and 0.05 µg/ml, respectively with >80% recovery. Maximum plasma concentration (Cmax ) following PO and IV administration was 8.805 and 4.497 µg/ml, respectively, while time to reach at maximum concentration (Tmax ) was 1 and 0.1 hr, respectively. The elimination half-lives were recorded as 1.02 and 0.978 hr, whereas the mean residence times were 1.79 and 1.036 hr following both PO and IV administration, respectively. The 85% PO bioavailability was indicative that TQ could be used for various therapeutic purposes in layer chickens.
中文翻译:
口服和静脉内给药后,胸腺鸡中胸腺醌的药代动力学。
胸腺醌(TQ)是黑变种(Nigella sativa)的主要成分,已知具有多种药理作用。此项研究旨在评估口服(PO)和静脉(IV)对蛋鸡的TQ的药代动力学特征。将产蛋鸡平均分为两组(每组六只鸡,共12只鸡),并通过PO和IV途径进行TQ。对于PO途径,剂量为20 mg / kg bw,对于IV途径,分别为5 mg / kg bw。验证了灵敏,准确的高效液相色谱(HPLC)技术用于定量测定血浆中的TQ。检测限(LOD)和定量限(LOQ)分别为0.02 µg / ml和0.05 µg / ml,回收率> 80%。PO和IV给药后的最大血浆浓度(Cmax)分别为8.805和4.497 µg / ml,而达到最大浓度(Tmax)的时间分别为1小时和0.1小时。消除半衰期分别记录为1.02和0.978小时,而口服和静脉给药后的平均停留时间分别为1.79和1.036小时。PO的85%的生物利用度表明TQ可用于蛋鸡的各种治疗目的。
更新日期:2019-11-01
中文翻译:
口服和静脉内给药后,胸腺鸡中胸腺醌的药代动力学。
胸腺醌(TQ)是黑变种(Nigella sativa)的主要成分,已知具有多种药理作用。此项研究旨在评估口服(PO)和静脉(IV)对蛋鸡的TQ的药代动力学特征。将产蛋鸡平均分为两组(每组六只鸡,共12只鸡),并通过PO和IV途径进行TQ。对于PO途径,剂量为20 mg / kg bw,对于IV途径,分别为5 mg / kg bw。验证了灵敏,准确的高效液相色谱(HPLC)技术用于定量测定血浆中的TQ。检测限(LOD)和定量限(LOQ)分别为0.02 µg / ml和0.05 µg / ml,回收率> 80%。PO和IV给药后的最大血浆浓度(Cmax)分别为8.805和4.497 µg / ml,而达到最大浓度(Tmax)的时间分别为1小时和0.1小时。消除半衰期分别记录为1.02和0.978小时,而口服和静脉给药后的平均停留时间分别为1.79和1.036小时。PO的85%的生物利用度表明TQ可用于蛋鸡的各种治疗目的。