Embryonic development requires the intricate balance between the expansion and specialisation of defined cell types in time and space. The gene expression programmes that underpin this balance are regulated, in part, by modulating the chemical and structural state of chromatin. Polycomb repressive complexes (PRCs), a family of essential developmental regulators, operate at this level to stabilise or perpetuate a repressed but transcriptionally poised chromatin configuration. This dynamic state is required to control the timely initiation of productive gene transcription during embryonic development. The two major PRCs cooperate to target the genome, but it is PRC1 that appears to be the primary effector that controls gene expression. In this review I will discuss recent findings relating to how PRC1 alters chromatin accessibility, folding and global 3D nuclear organisation to control gene transcription.

中文翻译：

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染色质折叠和核结构：PRC1在3D中起作用。

胚胎发育需要在时间和空间上扩展和特定细胞类型的专业化之间的复杂平衡。支撑这种平衡的基因表达程序部分地通过调节染色质的化学和结构状态来调节。聚梳抑制复合物（PRC）是必需的发育调节剂家族，可在此水平上稳定或维持受抑制但转录平衡的染色质构型。需要这种动态状态来控制胚胎发育过程中生产基因转录的及时启动。两个主要的PRCs共同靶向基因组，但PRC1似乎是控制基因表达的主要效应子。在这篇评论中，我将讨论有关PRC1如何改变染色质可及性的最新发现，