Conformationally heterogenous or "fuzzy" proteins have often been described as lacking specificity in binding and in function. The activation domains, for example, of transcriptional activators were labeled as negative noodles, with little structure or specificity. However, emerging data illustrates that the opposite is true: conformational heterogeneity enables context-specific function to emerge in response to changing cellular conditions and, furthermore, allows a single structural motif to be used in multiple settings. A further benefit is that conformational heterogeneity can be harnessed for the discovery of allosteric drug-like modulators, targeting critical pathways in protein homeostasis and transcription.

中文翻译：

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从模糊到功能：蛋白质-蛋白质相互作用的新领域。

形态上异质或“模糊”的蛋白质经常被描述为在结合和功能上缺乏特异性。例如，转录激活因子的激活域被标记为阴性面条，几乎没有结构或特异性。但是，新出现的数据表明事实恰恰相反：构象异质性使特定于上下文的功能能够响应不断变化的细胞条件而出现，此外，还允许在多个环境中使用单个结构基序。另一个好处是，可以利用构象异质性来发现变构药物样调节剂，靶向蛋白稳态和转录的关键途径。