Selenium (Se) is a trace element that incorporates into the selenoenzyme glutathione peroxidase (GSH-Px). There are conflicting results regarding the Se levels and activity of GSH-Px in adult uremic patients. The aim of this study was to determine (1) the hair Se status, (2) the possible relation between the hair Se status and the antioxidant enzyme, GSH-Px, and (3) the influence of different treatment procedures on hair Se status and GSH-Px activity in children with CRI, those treated conservatively and those on HD and on CAPD. Ninety-three patients, including 32 patients with CRI, treated conservatively, 42 PD patients, 19 HD patients and 34 healthy children were enrolled in the study. The hair Se level was measured by the atomic absorption spectrophotometer method. Plasma GSH-Px activity was determined using a Randox test combination (RANSEL). Hair Se levels were significantly lower in the CRI, CAPD, and HD groups when compared to the control group (P=0.001, P=0.001, and P=0.001, respectively). Plasma GSH-Px activity was significantly lower in the CRI, CAPD, and HD groups when compared to the control group (P=0.001, P=0.001, and P=0.001, respectively). Plasma GSH-Px activity correlated with the GFR in patients with CRI and the control group (P=0.000; r(2)=0.60). There was no correlation between plasma GSH-Px and hair Se levels in the patient and control groups. These results revealed a decreased hair Se level and impaired antioxidative capacity in children with CRI on CAPD and HD. The lack of any relation between plasma GSH-Px and hair Se suggests that plasma GSH-Px is not a good marker of Se stores.

中文翻译：

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慢性肾功能衰竭儿童的低发硒和血浆谷胱甘肽过氧化物酶。

硒（Se）是一种微量元素，可掺入硒酶谷胱甘肽过氧化物酶（GSH-Px）中。成人尿毒症患者的硒水平和GSH-Px活性存在矛盾的结果。这项研究的目的是确定（1）头发硒状态，（2）头发硒状态与抗氧化酶GSH-Px之间的可能关系，以及（3）不同处理程序对头发硒状态的影响CRI儿童，保守治疗的儿童以及接受HD和CAPD治疗的儿童的GSH-Px活性。保守治疗的93例患者（包括32例CRI患者），42例PD患者，19例HD患者和34例健康儿童参加了研究。头发Se水平通过原子吸收分光光度计法测量。使用Randox测试组合（RANSEL）测定血浆GSH-Px活性。与对照组相比，CRI，CAPD和HD组的头发Se水平显着降低（分别为P = 0.001，P = 0.001和P = 0.001）。与对照组相比，CRI，CAPD和HD组的血浆GSH-Px活性显着降低（分别为P = 0.001，P = 0.001和P = 0.001）。CRI患者和对照组的血浆GSH-Px活性与GFR相关（P = 0.000; r（2）= 0.60）。患者和对照组的血浆GSH-Px与头发Se水平之间没有相关性。这些结果表明，在CAPD和HD时，CRI患儿的头发硒水平降低，抗氧化能力受损。血浆GSH-Px与头发硒之间缺乏任何联系，表明血浆GSH-Px并不是硒存储的良好标志。与对照组相比，HD组和HD组（分别为P = 0.001，P = 0.001和P = 0.001）。与对照组相比，CRI，CAPD和HD组的血浆GSH-Px活性显着降低（分别为P = 0.001，P = 0.001和P = 0.001）。CRI患者和对照组的血浆GSH-Px活性与GFR相关（P = 0.000; r（2）= 0.60）。患者和对照组的血浆GSH-Px与头发Se水平之间没有相关性。这些结果表明，在CAPD和HD时，CRI患儿的头发硒水平降低，抗氧化能力受损。血浆GSH-Px与头发硒之间缺乏任何联系，表明血浆GSH-Px并不是硒存储的良好标志。与对照组相比，HD组和HD组（分别为P = 0.001，P = 0.001和P = 0.001）。与对照组相比，CRI，CAPD和HD组的血浆GSH-Px活性显着降低（分别为P = 0.001，P = 0.001和P = 0.001）。CRI患者和对照组的血浆GSH-Px活性与GFR相关（P = 0.000; r（2）= 0.60）。患者和对照组的血浆GSH-Px与头发Se水平之间没有相关性。这些结果表明，在CAPD和HD时，CRI患儿的头发硒水平降低，抗氧化能力受损。血浆GSH-Px与头发硒之间缺乏任何联系，表明血浆GSH-Px并不是硒存储的良好标志。与对照组相比，HD组和HD组（分别为P = 0.001，P = 0.001和P = 0.001）。CRI患者和对照组的血浆GSH-Px活性与GFR相关（P = 0.000; r（2）= 0.60）。患者和对照组的血浆GSH-Px与头发Se水平之间没有相关性。这些结果表明，CAPD和HD患CRI的儿童头发Se含量降低，抗氧化能力受损。血浆GSH-Px与头发硒之间缺乏任何联系，表明血浆GSH-Px并不是硒存储的良好标志。与对照组相比，HD组和HD组（分别为P = 0.001，P = 0.001和P = 0.001）。CRI患者和对照组的血浆GSH-Px活性与GFR相关（P = 0.000; r（2）= 0.60）。患者和对照组的血浆GSH-Px与头发Se水平之间没有相关性。这些结果表明，在CAPD和HD时，CRI患儿的头发硒水平降低，抗氧化能力受损。血浆GSH-Px与头发硒之间缺乏任何联系，表明血浆GSH-Px并不是硒存储的良好标志。这些结果表明，在CAPD和HD时，CRI患儿的头发硒水平降低，抗氧化能力受损。血浆GSH-Px与头发硒之间缺乏任何联系，表明血浆GSH-Px并不是硒存储的良好标志。这些结果表明，CAPD和HD患CRI的儿童头发Se含量降低，抗氧化能力受损。血浆GSH-Px与头发硒之间缺乏任何联系，表明血浆GSH-Px并不是硒存储的良好标志。