In rodents, pyramidal cell firing patterns from waking may be replayed in nonrapid eye movement sleep (NREM) sleep during hippocampal sharp wave ripples (HC‐SWR). In humans, HC‐SWR have only been recorded with electrodes implanted to localize epileptogenicity. Here, we characterize human HC‐SWR with rigorous rejection of epileptiform activity, requiring multiple oscillations and coordinated sharp waves. We demonstrated typical SWR in those rare HC recordings which lack interictal epileptiform spikes (IIS) and with no or minimal seizure involvement. These HC‐SWR have a similar rate (~12 min⁻¹ on average, variable across NREM stages and anterior/posterior HC) and apparent intra‐HC topography (ripple maximum in putative stratum pyramidale, slow wave in radiatum) as rodents, though with lower frequency (~85 Hz compared to ~140 Hz in rodents). Similar SWR are found in HC with IIS, but no significant seizure involvement. These SWR were modulated by behavior, being largely absent (<2 min⁻¹) except during NREM sleep in both Stage 2 (~9 min⁻¹) and Stage 3 (~15 min⁻¹), distinguishing them from IIS. This study quantifies the basic characteristics of a strictly selected sample of SWR recorded in relatively healthy human hippocampi.

中文翻译：

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改进了对 NREM 睡眠期间人类海马尖波涟漪的癫痫样活动的识别和区分。

在啮齿动物中，清醒时锥体细胞的放电模式可能会在海马尖波涟漪 (HC-SWR) 期间的非快速眼动睡眠 (NREM) 睡眠中重现。在人类中，仅在植入电极以定位致癫痫性的情况下记录了 HC-SWR。在这里，我们通过严格拒绝癫痫样活动来表征人类 HC-SWR，需要多次振荡和协调的锐波。我们在那些缺乏发作间期癫痫样尖峰 (IIS) 并且没有或很少涉及癫痫发作的罕见 HC 记录中证明了典型的 SWR。这些 HC-SWR 具有相似的速率（~12 min ^-1平均而言，在 NREM 阶段和前/后 HC 之间变化）和明显的内部 HC 地形（假定的锥体层中的最大波纹，辐射中的慢波）作为啮齿动物，尽管频率较低（~85 Hz 与啮齿动物中的~140 Hz 相比） ）。在具有 IIS 的 HC 中发现了类似的 SWR，但没有明显的癫痫发作。这些SWR由行为调制，是基本上不存在（<2分钟^-1），除了在NREM睡眠两者第2阶段（〜9分钟期间^-1）和第3阶段（〜15分钟^-1），从IIS区分它们。本研究量化了在相对健康的人类海马中记录的严格选择的 SWR 样本的基本特征。