Some previous studies already explored associations between paraoxonase 1 (PON1) polymorphisms and cancer, with conflicting findings. Here, we aimed to better analyse the relationship between PON1 polymorphisms and cancer in a larger combined population by performing a meta-analysis. We searched PubMed, Embase, and Web of Science for related articles. We calculated odds ratio (OR) and 95% confidence interval (CI) to estimate whether there are genetic associations between PON1 polymorphisms and cancer. Forty studies were included for this meta-analysis. The PON1 rs854560 polymorphism (L55M) was found to be significantly associated with cancer in general population (dominant comparison: p = .04, OR = 0.85, 95%CI 0.73-0.99; recessive comparison: p = .007, OR = 1.27, 95%CI 1.07-1.51; allele comparison: p = 0.02, OR = 0.85, 95%CI 0.75-0.97). Subgroup analyses indicated that the significant findings were mainly driven by the haematological tumours and breast cancer subgroups. We did not observe any positive findings for PON1 rs662 polymorphism (Q192R) in combined analyses. In summary, this meta-analysis proved that PON1 rs854560 polymorphism could be used to identify individual with elevated susceptibility to cancer, especially for haematological tumours and breast cancer.

中文翻译：

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对氧磷酶1多态性与癌症之间关系的荟萃分析。

先前的一些研究已经探索了对氧磷酶1（PON1）多态性与癌症之间的关联，但发现却相互矛盾。在这里，我们旨在通过进行荟萃分析，更好地分析更大的合并人群中PON1基因多态性与癌症之间的关系。我们在PubMed，Embase和Web of Science中搜索了相关文章。我们计算了优势比（OR）和95％置信区间（CI），以估计PON1多态性与癌症之间是否存在遗传关联。这项荟萃分析包括40项研究。发现PON1 rs854560多态性（L55M）与普通人群的癌症显着相关（主要比较：p = .04，OR = 0.85，95％CI 0.73-0.99;隐性比较：p = .007，OR = 1.27， 95％CI 1.07-1.51；等位基因比较：p = 0.02，OR = 0.85，95％CI 0.75-0.97）。亚组分析表明，重要发现主要由血液肿瘤和乳腺癌亚组驱动。在合并分析中，我们未发现PON1 rs662多态性（Q192R）的任何阳性发现。总之，这项荟萃分析证明，PON1 rs854560基因多态性可用于鉴定对癌症特别是血液肿瘤和乳腺癌易感性高的个体。