Spinal cord injury (SCI) is a common pathological condition that leads to permanent or temporal loss of motor and autonomic functions. Kainic acid (KA), an agonist of kainate receptors, a type of ionotropic glutamate receptor, is widely used to induce experimental neurodegeneration models of CNS. Mesenchymal Stem Cells (MSC) therapy applied at the injured nervous tissue have emerged as a promising therapeutic treatment. Here we used a validated SCI experimental model in which an intraparenchymal injection of KA into the C5 segment of rat spinal cord induced an excitotoxic lesion. Three days later, experimental animals were treated with an intracerebroventricular injection of human umbilical cord (hUC) MSC whereas control group only received saline solution. Sensory and motor skills as well as neuronal and glial reaction of both groups were recorded. Differences in motor behavior, neuronal counting and glial responses were observed between hUC-MSC-treated and untreated rats. According to the obtained results, we suggest that hUC-MSC therapy delivered into the fourth ventricle using the intracerebroventricular via can exert a neuroprotective or neurorestorative effect on KA-injected animals.

中文翻译：

---

脑室的人脐带间充质干细胞的脑室交付作为修复红藻氨酸引起的脊髓损伤的有前途的治疗方法。

脊髓损伤（SCI）是一种常见的病理状况，会导致永久性或暂时性的运动和自主功能丧失。海藻酸（KA），一种海盐受体的激动剂，一种离子型谷氨酸受体，被广泛用于诱导中枢神经系统的实验性神经变性模型。在受损的神经组织上应用间充质干细胞（MSC）治疗已成为一种有前途的治疗方法。在这里，我们使用一个经过验证的SCI实验模型，其中将实质性内部KA注射到大鼠脊髓的C5节中诱发了兴奋性毒性病变。三天后，脑室内注射人脐带（hUC）MSC对实验动物进行治疗，而对照组仅接受盐溶液。记录两组的感觉和运动技能以及神经元和神经胶质反应。在hUC-MSC治疗和未治疗的大鼠之间观察到运动行为，神经元计数和神经胶质反应的差异。根据获得的结果，我们建议使用脑室内通孔将hUC-MSC疗法递送至第四脑室可以对注射KA的动物发挥神经保护或神经修复作用。