In the present study, the possible activation of cellular immunity in SCD patients was investigated. As immune activation parameters, neopterin concentrations and kynurenine/tryptophan ratio for tryptophan degradation in 35 pediatric patients with sickle cell disease (31 HbSS and 4 HbSß) were determined. Our results have shown that neopterin levels (both urinary and serum) are increased in pediatric patients with sickle cell disease. The increase in neopterin concentration was accompanied by significantly increased biopterin, kynurenine concentration and kynurenine/tryptophan ratio. The mechanism of immune activation and the effects of inflammatory mediators in sickle cell disease are poorly understood, especially in terms of cell-mediated immunity. Further in-vivo and in-vitro studies are required to illuminate the association between neopterin levels and neutrophil activation in sickle cell disease.

中文翻译：

---

镰状细胞性贫血的土耳其小儿患者的新蝶呤含量增加。

在本研究中，研究了SCD患者细胞免疫的可能激活。作为免疫激活参数，测定了35名镰状细胞病（31 HbSS和4HbSß）患儿的色氨酸降解的新蝶呤浓度和犬尿氨酸/色氨酸比率。我们的结果表明，镰状细胞病患儿的新蝶呤水平（尿液和血清）增加。新蝶呤浓度的增加伴随着生物蝶呤，犬尿氨酸浓度和犬尿氨酸/色氨酸比的显着增加。镰状细胞疾病中免疫激活的机制和炎性介质的作用知之甚少，尤其是在细胞介导的免疫方面。