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Rheumatoid arthritis and cognition dysfunction: lack of association with cumulative glucocorticoid use.
Immunopharmacology and Immunotoxicology ( IF 3.3 ) Pub Date : 2019-10-19 , DOI: 10.1080/08923973.2019.1679170
Fernanda Almeida Said 1 , Tatiane Bellafronte Betoni 1 , Vicente Magalhaes 1 , Renato Nisihara 1, 2 , Thelma L Skare 1, 3
Affiliation  

Aim: To study if cumulative glucocorticoid use could be related to cognitive impairment in rheumatoid arthritis (RA) patients.Methods: A sample of 60 RA patients and 64 controls were studied for the Mini Mental State Examination (MMSE) and depression scale (using CES-D or Center for Epidemiological Studies Depression scale). RA patients also filled a visual analogic scale (VAS) of pain and had disease activity evaluated by DAS-28 ESR (disease activity score using erythrocyte sedimentation rate). Clinical and treatment data, including cumulative dose of glucocorticoid, were collected from the charts.Results: Patients with RA had more cognitive impairment and depression than controls (p = .002 and .03, respectively). A weak and negative association of MMSE with VAS of pain was found (rho= -0.16; 95%CI = 0.49-0.004; p = .04) but not with depression and cumulative glucocorticoid doses (p = .22 and p = .52, respectively).Conclusion: Although RA patients have more cognitive impairment than controls, no correlation of this problem with cumulative glucocorticoid doses was found.

中文翻译:

类风湿关节炎和认知功能障碍:缺乏与糖皮质激素累积使用的关联。

目的:研究类风湿关节炎(RA)患者糖皮质激素的累积使用是否与认知功能障碍有关。方法:对60例RA患者和64名对照进行了抽样研究,以进行迷你精神状态检查(MMSE)和抑郁量表(使用CES) -D或流行病学研究中心抑郁量表)。RA患者还可以通过视觉模拟量表(VAS)评估疼痛程度,并通过DAS-28 ESR评估疾病活动性(使用红细胞沉降率的疾病活动性评分)。从图表中收集临床和治疗数据,包括糖皮质激素的累积剂量。结果:RA患者的认知障碍和抑郁症比对照组多(分别为p = 0.002和.03)。发现MMSE与疼痛的VAS之间存在弱和负相关性(rho = -0.16; 95%CI = 0.49-0.004; p =。
更新日期:2019-11-01
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