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Dynamic acetylation profile during mammalian neurulation.
Birth Defects Research ( IF 2.1 ) Pub Date : 2019-11-23 , DOI: 10.1002/bdr2.1618
Valentina Massa 1 , Laura Avagliano 1 , Paolo Grazioli 1 , Sandra C P De Castro 2 , Chiara Parodi 1 , Dawn Savery 2 , Patrizia Vergani 3 , Serena Cuttin 4 , Patrizia Doi 1 , Gaetano Bulfamante 1 , Andrew J Copp 2 , Nicholas D E Greene 2
Affiliation  

Neural tube defects (NTDs) result from failure of neural tube closure during embryogenesis. These severe birth defects of the central nervous system include anencephaly and spina bifida, and affect 0.5–2 per 1,000 pregnancies worldwide in humans. It has been demonstrated that acetylation plays a pivotal role during neural tube closure, as animal models for defective histone acetyltransferase proteins display NTDs. Acetylation represents an important component of the complex network of posttranslational regulatory interactions, suggesting a possible fundamental role during primary neurulation events. This study aimed to assess protein acetylation contribution to early patterning of the central nervous system both in human and murine specimens.

中文翻译:

哺乳动过程中的动态乙酰化过程。

神经管缺陷(NTD)是由于胚胎发生过程中神经管闭合失败而引起的。这些中枢神经系统的严重先天缺陷包括无脑和脊柱裂,在全球每1000例怀孕中有0.5–2例发生。已经证明乙酰化在神经管闭合过程中起着关键作用,因为有缺陷的组蛋白乙酰转移酶蛋白的动物模型显示NTD。乙酰化代表了翻译后调节相互作用的复杂网络的重要组成部分,暗示了在初级神经事件中可能的基本作用。这项研究旨在评估人和鼠标本中蛋白质乙酰化对中枢神经系统早期模式的贡献。
更新日期:2019-11-23
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