Cancer Stem Cells/Cancer Initiating Cells (CSCs/CICs) is a rare sub-population within a tumor that is responsible for tumor formation, progression and resistance to therapies. The interaction between CSCs/CICs and tumor microenvironment (TME) can sustain “stemness” properties and promote their survival and plasticity. This cross-talk is also pivotal in regulating and modulating CSC/CIC properties. This review will provide an overview of the mechanisms underlying the mutual interaction between CSCs/CICs and TME. Particular focus will be dedicated to the immunological profile of CSCs/CICs and its role in orchestrating cancer immunosurveillance. Moreover, the available immunotherapy strategies that can target CSCs/CICs and of their possible implementation will be discussed. Overall, the dissection of the mechanisms regulating the CSC/CIC-TME interaction is warranted to understand the plasticity and immunoregulatory properties of stem-like tumor cells and to achieve complete eradications of tumors through the optimization of immunotherapy.

中文翻译：

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癌症干细胞/癌症起始细胞与肿瘤微环境之间的相互交谈：免疫疗法有效靶向这些细胞的难题之谜。

癌症干细胞/癌症起始细胞（CSC / CIC）是肿瘤中罕见的亚群，其负责肿瘤的形成，进展和对治疗的耐药性。CSC / CIC与肿瘤微环境（TME）之间的相互作用可以维持“干性”特性并促进其生存和可塑性。这种串扰在调节和调节CSC / CIC特性方面也至关重要。这篇综述将概述CSC / CIC与TME之间相互交互的基础机制。将特别关注CSCs / CIC的免疫学特征及其在协调癌症免疫监测中的作用。此外，将讨论可针对CSCs / CICs的可用免疫疗法策略及其可能的实施方式。总体，