This study is based on our already published experimental data (Kowalska et al. in Radiat Environ Biophys 58:99-108, 2019) and is devoted to modeling of chromosome aberrations in human lymphocytes induced by 22.1 MeV/u 11B ions, 199 MeV/u 12C ions, 150 MeV and spread-out Bragg peak (SOBP) proton beams as well as by 60Co γ rays. The curvature of the dose-effect curves determined by the linear-quadratic model was considered in the frame of a simple analytical approach taking into account increase in the irradiation dose due to overlapping interaction regions of ion tracks. The model enabled to estimate effective interaction radius which could be compared with the physical expectations. The results were also compared to the Amorphous Track Structure Model of Katz which allows to get some additional information about the ion track structure. The analysis showed that the curvature of the experimental dose-effect curves mainly results from highly efficient repair processes of the DNA damage.

中文翻译：

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具有不同LET的粒子束引起的染色体畸变响应函数的建模。

这项研究基于我们已经发布的实验数据（Kowalska等人在Radiat Environ Biophys 58：99-108，2019），致力于模拟由22.1 MeV / u 11B离子，199 MeV /引起的人淋巴细胞染色体畸变的建模。 u 12C离子，150 MeV和展开的布拉格峰（SOBP）质子束以及60Coγ射线。在简单分析方法的框架内考虑了由线性二次模型确定的剂量效应曲线的曲率，并考虑了由于离子轨迹相互作用区域重叠而导致的辐照剂量增加。该模型能够估算有效的相互作用半径，可以将其与物理期望值进行比较。还将结果与Katz的非晶轨道结构模型进行了比较，该模型允许获得有关离子轨道结构的一些其他信息。