PURPOSE To re-assess the scientific literature to ascertain if there is scientific evidence to support antibiotic prophylaxis in patients with periodontal disease as a means to decrease the risk of prosthetic joint infections. INTRODUCTION Prosthetic joint infections occur in approximately 0.3-2% of patients and, of these, around 6-13% are thought to be caused by oral bacteria. Antibiotic prophylaxis prior to dental procedures as a means to prevent a prosthetic joint infection has been controversial throughout the years. However, it remains unclear to what extent it has a beneficial effect. We do know that bacteraemia of oral origin is directly proportional to any ongoing inflammation or infection, and that a diseased periodontium may act as an entry for bacteria to spread to distant locations, through the bloodstream, and potentially be the cause of distant site infections. MATERIALS AND METHODS Updated literature search using the PubMed (Medline), and the Clarivate Analytics databases, to identify eligible articles since the previous searches up to April 2019 (last 5 years). RESULTS No studies that relate periodontal disease to the development of a prosthetic joint infection were found. CONCLUSION Currently, there is no evidence to support or exclude the need of antibiotic prophylaxis as a means to decrease the risk of prosthetic joint infections in patients with periodontal disease.

中文翻译：

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是否有科学证据支持对牙周病患者进行抗生素预防，以降低关节假体感染的风险？系统的审查。

目的重新评估科学文献，以确定是否有科学证据支持对牙周病患者进行抗生素预防，以减少假体关节感染的风险。简介人工关节感染发生在约0.3-2％的患者中，其中约6-13％被认为是由口腔细菌引起的。多年来，在牙科手术之前预防抗生素作为预防假体关节感染的方法一直存在争议。但是，尚不清楚它在何种程度上具有有益作用。我们确实知道口腔来源的菌血症与任何正在进行的炎症或感染都成正比，并且患病的牙周膜可能是细菌通过血流传播到远处的入口，并可能是远处感染的原因。材料和方法使用PubMed（Medline）和Clarivate Analytics数据库更新了文献搜索，以识别自上次搜索到2019年4月（过去5年）以来的合格文章。结果未发现将牙周疾病与假体关节感染发展相关的研究。结论当前，尚无证据支持或排除需要抗生素预防作为降低牙周疾病患者人工关节感染风险的方法。结果未发现将牙周疾病与假体关节感染发展相关的研究。结论当前，尚无证据支持或排除需要抗生素预防作为降低牙周疾病患者人工关节感染风险的方法。结果未发现将牙周疾病与假体关节感染发展相关的研究。结论当前，尚无证据支持或排除使用抗生素预防作为降低牙周疾病患者人工关节感染风险的方法。