In vivo load and motion in the ankle joint play a key role in the understanding of the failure mechanism and function outcomes of total ankle arthroplasty. However, a thorough understanding of the biomechanics of the ankle joint in daily activities is lacking. The objective of this study was to develop a novel lower extremity musculoskeletal multibody dynamics model with total ankle arthroplasty considering the 6 degrees of freedom of the ankle joint motions and the deformable contact mechanics of the implant, based on force-dependent kinematics method. A patient who underwent total ankle arthroplasty surgery was considered. The walking gait data of the patient was measured in a gait laboratory and used as the input for the patient-specific musculoskeletal modeling. The predictions from the musculoskeletal model of total ankle arthroplasty included dorsiflexion-plantar flexion, inversion-eversion, internal-external rotation, anterior-posterior translation, inferior-superior translation, and medial-lateral translation of the tibiotalar joint, the ankle contact forces, the muscle activations, and the ligament forces. The magnitudes and tendencies of the predicted results were all within reasonable ranges, as compared with the data available in the literature. The predicted peak total ankle contact force was 6.55 body weight. In addition, the peak contact forces of the lateral and medial compartments were 4.22 body weight and 2.59 body weight, respectively. This study provides a potential new platform for the design of a better ankle prosthesis, the improvement of the operation techniques of the clinicians, and the accelerated postoperative recovery of the patients.

中文翻译：

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使用力依赖运动学预测体内关节力学的全踝关节置换术的肌肉骨骼建模。

踝关节的体内负荷和运动在了解全踝关节置换术的失败机制和功能结果方面起着关键作用。但是，缺乏对日常活动中踝关节生物力学的透彻了解。这项研究的目的是基于力依赖运动学方法，开发一种具有全踝关节置换术的新型下肢肌肉骨骼多体动力学模型，其中考虑了踝关节运动的6个自由度和植入物的可变形接触力学。考虑接受全踝关节置换手术的患者。在步态实验室中测量患者的步行步态数据，并将其用作患者特定的肌肉骨骼模型的输入。全踝关节置换的肌肉骨骼模型的预测包括背屈-足底屈曲，内翻-外翻，内-外旋转，胫骨tal关节的前-后平移，上下平移和内侧-外侧平移，踝关节接触力，肌肉激活和韧带力量。与文献中可用的数据相比，预测结果的幅度和趋势均在合理范围内。预计最大总踝关节接触力为6.55体重。另外，外侧和内侧隔室的峰值接触力分别为4.22体重和2.59体重。这项研究为设计更好的踝关节假体，改善临床医生的手术技术提供了潜在的新平台，