Prolonged contact of healthy subjects with Mycobacterium tuberculosis can change their blood formula and immune status, thus reflecting adaptive reactions to constant antigenic load. The peripheral blood analysis of health care workers in a tuberculosis hospital demonstrates changes in cell populations which prevent development of tuberculosis, in particular, CD4+ Т cells and CD3+ Т cells. It is shown that the number of the memory CD4+ Т cells specific to M.tuberculosis antigens which produce interferon gamma depends on the duration of work contact with tuberculosis patients. The use of health care workers' blood characteristics as a control for tuberculosis patients is discussed.

中文翻译：

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长期接触结核病患者的健康受试者反应分析。

健康受试者与结核分枝杆菌的长时间接触会改变其血液配方和免疫状态，从而反映出对恒定抗原负荷的适应性反应。在结核病医院对医护人员进行的外周血分析表明，阻止结核病发展的细胞群发生了变化，特别是CD4 +Т细胞和CD3 +Т细胞。结果表明，产生干扰素γ的结核分枝杆菌抗原特异的记忆CD4 +Т细胞数量取决于与结核病患者接触的时间。讨论了使用医护人员的血液特征作为结核病患者的对照。