C/EBP-β, a basic leucine zipper transcription factor, has important roles in the regulation of the body immune and inflammatory responses. Wistar rats subjected to combined irradiation were characterized by an increase in the content of the C/EBP-β LIP isoform in the pituitary gland. The obtained data indicate that moderate doses of ionizing radiation to initiate the endoplasmic reticulum stress response and are likely to initiate C/EBP-β-mediated cell death according to the apoptotic scenario. This study also confirms the earlier hypothesis about the alterations of the hypothalamic-pituitary-adrenocortical axis in response to moderate doses of ionizing radiation.

中文翻译：

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γ射线和碳核联合照射可增加大鼠垂体C /EBP-βLIP亚型的含量。

C /EBP-β是一种基本的亮氨酸拉链转录因子，在调节人体免疫和炎症反应中具有重要作用。接受联合照射的Wistar大鼠的特征是垂体中C /EBP-βLIP亚型的含量增加。所获得的数据表明，根据凋亡的情况，中等剂量的电离辐射可引发内质网应激反应，并可能引发C /EBP-β介导的细胞死亡。这项研究还证实了关于中等剂量电离辐射下丘脑-垂体-肾上腺皮质轴改变的早期假设。