Abstract

An endophytic fungus Pestalotiopsis microspora isolated from the fruits of Manilkara zapota was cultured in potato dextrose broth media. Chromatographic separation of the EtOAc extract of the broth and mycelium led to the isolation of a new azaphilonoid named pitholide E (1), in addition to previously identified pitholide B (2), pitholide D (3), pestalotin (LL-P880α) (4), PC-2 (5), LL-P880β (6), tyrosol (7) and 4-oxo-4H-pyran-3-acetic acid (8). An endophytic fungus P. microspora from M. zapota and the isolation of compounds 1–5, 7 and 8 from P. microspora are reported here for the first time.

Graphic Abstract

中文翻译：

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由内生真菌小孢拟盘拟盘菌产生的次生代谢物。

摘要

在马铃薯葡萄糖肉汤培养基中培养从Manilkara zapota果实中分离的内生真菌小孢拟盘菌。对肉汤和菌丝体的 EtOAc 提取物进行色谱分离，除了先前鉴定的 Pitholide B ( 2 )、Pitholide D ( 3 )、pestalotin (LL-P880α) ( 4 )、PC-2( 5 )、LL-P880β( 6 )、酪醇( 7 )和4-氧代-4H-吡喃-3-乙酸( 8 )。本文首次报道了来自M. zapota的内生真菌P. microspora以及从P. microspora中分离出化合物1 – 5、7和8 。

图文摘要