Purpose

Approximately 5.7 million people in the US are affected by congestive heart failure. This study aimed to quantitatively evaluate cardiothoracic morphology and variability within a cohort of heart failure patients for the purpose of optimally engineering cardiac devices for a variety of heart failure patients.

Methods

Co-registered cardiac-gated and non-gated chest computed tomography (CT) scans were analyzed from 20 heart failure patients (12 males; 8 females) who were primarily older adults (79.5 ± 8.8 years). Twelve cardiothoracic measurements were collected and compared to study sex and left ventricular (LV) ejection fraction (EF) type differences in cardiothoracic morphology.

Results

Four measures were significantly greater in males compared to females: LV long-axis length, LV end diastolic diameter (LVEDD) at 50% length of the LV long-axis, the minimal distance between the sternum and heart, and the angle between the LV long-axis and coronal plane. Four measures were significantly greater in patients with reduced EF compared to preserved LV: LV long-axis length, LVEDD at 50% length of the LV long-axis, left ventricular volume normalized by body surface area, and the angle between the mitral valve plane and LV long-axis.

Conclusions

These cardiothoracic morphology measurements are important to consider in the design of cardiac devices for heart failure management (e.g. cardiac pacemakers, ventricular assist devices, and implantable defibrillators), since morphology differs by sex and ejection fraction.

中文翻译：

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心力衰竭患者的心胸形态学测量，以告知装置设计。

目的

在美国，约有570万人患有充血性心力衰竭。这项研究旨在定量评估一组心力衰竭患者的心胸形态和变异性，以针对各种心力衰竭患者优化心脏设备的目的。

方法

对20位心力衰竭患者（12例男性； 8例女性）中主要年龄较大的成年人（79.5±8.8岁）进行了共同注册的心脏门控和非门控胸部计算机断层扫描（CT）扫描。收集了十二个心胸测量值，并比较了心胸形态学中的性别和左心室（LV）射血分数（EF）类型差异。

结果

与女性相比，男性的四个指标明显更高：LV长轴长度，LV长轴长度的50％时的LV舒张末期直径（LVEDD），胸骨与心脏之间的最小距离以及LV之间的角度长轴和冠状平面。与保留的LV相比，EF降低的患者有四个指标明显更高：LV长轴长度，LV长轴长度的50％处的LVEDD，通过体表面积归一化的左心室容积以及二尖瓣平面之间的夹角和LV长轴。

结论

这些心胸形态学测量在设计用于心力衰竭的心脏设备（例如心脏起搏器，心室辅助设备和植入式除纤颤器）时必须考虑到，因为形态在性别和射血分数方面有所不同。