Anticipation is a universal preparatory response essential to the survival of an organism. Although meta-analytic synthesis of the literature exists for the anticipation of reward, a neuroimaging-based meta-analysis of the neural mechanisms of aversive anticipation is lacking. To address this gap in the literature, we ran an activation likelihood estimate (ALE) meta-analysis of 63 fMRI studies of aversive anticipation across multiple sensory modalities. Results of the ALE meta-analysis provide evidence for a core circuit involved in aversive anticipation, including the anterior insula, anterior cingulate cortex, mid-cingulate cortex, amygdala, thalamus, and caudate nucleus among other regions. Direct comparison of aversive anticipation studies using tactile versus visual stimuli identified additional regions involved in sensory specific aversive anticipation across these sensory modalities. Results from complementary multi-study voxel-wise and NeuroSynth analyses generally provide converging evidence for a core circuit involved in aversive anticipation. The multi-study voxel-wise analyses also implicate a more widespread preparatory response across sensory, motor, and cognitive control regions during more prolonged periods of aversive anticipation. The potential roles of these structures in anticipatory processing as well as avenues for future research are discussed.

中文翻译：

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厌恶预期的神经相关性：跨多种感觉模态的激活可能性估计值荟萃分析。

预期是对生物体生存必不可少的普遍准备反应。尽管文献的荟萃分析综合可用于预期奖励，但仍缺乏基于神经影像的厌恶预期神经机制的荟萃分析。为了弥补文献中的这一空白，我们对63种功能性MRI研究进行了激活似然估计（ALE）荟萃分析，这些研究涉及多种感觉模态。ALE荟萃分析的结果为参与反感预期的核心回路提供了证据，包括其他部位之间的前岛，前扣带回皮层，中扣带回皮层，杏仁核，丘脑和尾状核。使用触觉刺激和视觉刺激进行厌恶预期研究的直接比较，确定了在这些感觉方式上涉及感觉特异性厌恶预期的其他区域。互补的多研究体素和NeuroSynth分析的结果通常为涉及厌恶预期的核心电路提供了越来越多的证据。多项研究的体素分析还暗示了在更长时间的厌恶预期期间，跨感觉，运动和认知控制区域的准备反应更加广泛。讨论了这些结构在预期处理中的潜在作用以及未来研究的途径。互补的多研究体素和NeuroSynth分析的结果通常为涉及厌恶预期的核心电路提供了越来越多的证据。多项研究的体素分析还暗示了在更长时间的厌恶预期期间，跨感觉，运动和认知控制区域的准备反应更加广泛。讨论了这些结构在预期处理中的潜在作用以及未来研究的途径。互补的多研究体素和NeuroSynth分析的结果通常为涉及厌恶预期的核心电路提供了越来越多的证据。多项研究的体素分析还暗示了在更长时间的厌恶预期期间，跨感觉，运动和认知控制区域的准备反应更加广泛。讨论了这些结构在预期处理中的潜在作用以及未来研究的途径。