Metabolic syndrome (MetS) is a risk factor for type 2 diabetes mellitus and cardiovascular disease. Obesity is a component of the metabolic syndrome. Several genetic variants are reported to be associated with obesity and hypo adiponectinemia, including ars1800796 polymorphism of the interleukin-6 (IL-6) gene. Since obesity is associated with inflammatory factors, the aim of this study was to investigate the association between this polymorphism and MetS and its related features. Obese patients with body mass index (BMI) ≥ 30 (n = 182) were recruited into this study and divided into two groups; 110 patients with MetS, based on the International Diabetes Federation (IDF) criteria, and 72 subjects without MetS. The anthropometric and biochemical data for the groups were compared. Genotyping was carried out using RT-PCR. The association of the genetic polymorphism with MetS and its components were assessed using univariate and multivariate analyzes. There was an association between the presence of the rs1800796polymorphism of the IL-6 gene, with BMI (P = 0.031), high-density lipoprotein (HDL) (P = 0.010) and low-density lipoprotein (LDL) (P = 0.037), while this genetic variant did not show any significant association with the presence of MetS as defined by the IDF. We demonstrate an association between the rs1800796 genetic variant of the IL-6 gene with components of MetS including BMI, and HDL-cholesterol, but not the MetS itself. Therefore, supporting further studies are warranted to investigate this point in a larger population.

中文翻译：

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IL6基因多态性与肥胖人群代谢综合征成分特征的关系。

代谢综合症（MetS）是2型糖尿病和心血管疾病的危险因素。肥胖是代谢综合征的一部分。据报道，有几种遗传变异与肥胖和低脂联素血症有关，包括白细胞介素6（IL-6）基因的ars1800796多态性。由于肥胖与炎症因子有关，因此本研究的目的是研究这种多态性与MetS及其相关特征之间的关联。肥胖患者的体重指数（BMI）≥30（n = 182）被纳入这项研究，并分为两组；根据国际糖尿病联合会（IDF）标准，有110名患有MetS的患者和72名无MetS的受试者。比较了各组的人体测量学和生化数据。使用RT-PCR进行基因分型。使用单变量和多变量分析评估了遗传多态性与MetS及其组成的关联。IL-6基因的rs1800796多态性与BMI（P  = 0.031），高密度脂蛋白（HDL）（P  = 0.010）和低密度脂蛋白（LDL）之间存在相关性（P = 0.037），而该遗传变异与IDF定义的MetS的存在没有任何显着关联。我们证明了IL-6基因的rs1800796遗传变异与MetS包括BMI和HDL-胆固醇的组成部分之间的关​​联，而与MetS本身无关。因此，有必要进行更多的研究以调查更多人群中的这一点。