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Tumour-infiltrating lymphocytes in canine melanocytic tumours: An investigation on the prognostic role of CD3+ and CD20+ lymphocytic populations.
Veterinary and Comparative Oncology ( IF 2.1 ) Pub Date : 2019-12-11 , DOI: 10.1111/vco.12556 Ilaria Porcellato 1 , Serenella Silvestri 1 , Laura Menchetti 1 , Francesca Recupero 1 , Luca Mechelli 1 , Monica Sforna 1 , Selina Iussich 2 , Laura Bongiovanni 3 , Elvio Lepri 1 , Chiara Brachelente 1
Veterinary and Comparative Oncology ( IF 2.1 ) Pub Date : 2019-12-11 , DOI: 10.1111/vco.12556 Ilaria Porcellato 1 , Serenella Silvestri 1 , Laura Menchetti 1 , Francesca Recupero 1 , Luca Mechelli 1 , Monica Sforna 1 , Selina Iussich 2 , Laura Bongiovanni 3 , Elvio Lepri 1 , Chiara Brachelente 1
Affiliation
The study of the immune response in several types of tumours has been rapidly increasing in recent years with the dual aim of understanding the interactions between neoplastic and immune cells and their importance in cancer pathogenesis and progression, as well as identifying targets for cancer immunotherapy. Despite being considered one of the most immunogenic tumour types, melanoma can progress in the presence of abundant lymphocytic infiltration, therefore suggesting that the immune response is not able to efficiently control tumour growth. The purpose of this study was to investigate whether the density, distribution and grade of tumour‐infiltrating lymphocytes (TILs) in 97 canine melanocytic tumours is associated with histologic indicators of malignancy and can be considered a prognostic factor in the dog. As a further step in the characterization of the immune response in melanocytic tumours, an immunohistochemical investigation was performed to evaluate the two main populations of TILs, T‐lymphocytes (CD3+) and B‐lymphocytes (CD20+). The results of our study show that TILs are present in a large proportion of canine melanocytic tumours, especially in oral melanomas, and that the infiltrate is usually mild. The quantity of CD20+ TILs was significantly associated with some histologic prognostic factors, such as the mitotic count, the cellular pleomorphism and the percentage of pigmented cells. Remarkably, a high infiltration of CD20+ TILs was associated with tumour‐related death, presence of metastasis/recurrence, shorter overall and disease‐free survival, increased hazard of death and of developing recurrence/metastasis, hence representing a potential new negative prognostic factor in canine melanocytic tumours.
中文翻译:
犬黑素细胞瘤中的肿瘤浸润淋巴细胞:CD3 +和CD20 +淋巴细胞群的预后作用研究。
近年来,针对几种类型的肿瘤的免疫应答的研究迅速增长,其双重目的是理解肿瘤与免疫细胞之间的相互作用及其在癌症发病机理和进展中的重要性,以及确定癌症免疫疗法的目标。尽管被认为是最具免疫原性的肿瘤类型之一,但黑色素瘤仍可在大量淋巴细胞浸润的情况下进展,因此表明免疫反应无法有效控制肿瘤的生长。这项研究的目的是调查97种犬黑素细胞肿瘤中肿瘤浸润淋巴细胞(TILs)的密度,分布和等级是否与恶性组织学指标相关,并且可以被视为狗的预后因素。+)和B淋巴细胞(CD20 +)。我们的研究结果表明,TILs在犬黑素细胞肿瘤中占很大比例,尤其是在口腔黑素瘤中,并且浸润通常较轻。CD20 + TILs的数量与一些组织学预后因素显着相关,例如有丝分裂计数,细胞多态性和色素细胞百分比。值得注意的是,CD20 + TIL的高度浸润与肿瘤相关的死亡,转移/复发的存在,更短的总体生存率和无病生存,死亡的风险增加以及发生复发/转移有关,因此代表了潜在的新的阴性预后因素在犬黑素细胞瘤中。
更新日期:2019-12-11
中文翻译:
犬黑素细胞瘤中的肿瘤浸润淋巴细胞:CD3 +和CD20 +淋巴细胞群的预后作用研究。
近年来,针对几种类型的肿瘤的免疫应答的研究迅速增长,其双重目的是理解肿瘤与免疫细胞之间的相互作用及其在癌症发病机理和进展中的重要性,以及确定癌症免疫疗法的目标。尽管被认为是最具免疫原性的肿瘤类型之一,但黑色素瘤仍可在大量淋巴细胞浸润的情况下进展,因此表明免疫反应无法有效控制肿瘤的生长。这项研究的目的是调查97种犬黑素细胞肿瘤中肿瘤浸润淋巴细胞(TILs)的密度,分布和等级是否与恶性组织学指标相关,并且可以被视为狗的预后因素。+)和B淋巴细胞(CD20 +)。我们的研究结果表明,TILs在犬黑素细胞肿瘤中占很大比例,尤其是在口腔黑素瘤中,并且浸润通常较轻。CD20 + TILs的数量与一些组织学预后因素显着相关,例如有丝分裂计数,细胞多态性和色素细胞百分比。值得注意的是,CD20 + TIL的高度浸润与肿瘤相关的死亡,转移/复发的存在,更短的总体生存率和无病生存,死亡的风险增加以及发生复发/转移有关,因此代表了潜在的新的阴性预后因素在犬黑素细胞瘤中。