Background: High altitude sojourn challenges blood flow regulation in the brain, which may contribute to cognitive dysfunction. Neurovascular coupling (NVC) describes the ability to increase blood flow to working regions of the brain. Effects of high altitude on NVC in frontal regions undergoing cognitive activation are unclear but may be relevant to executive function in high-altitude hypoxia. This study sought to examine the effect of incremental ascent to very high altitude on NVC by measuring anterior cerebral artery (ACA) and middle cerebral artery (MCA) hemodynamic responses to sustained cognitive activity.

中文翻译：

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在海拔上升过程中，在前脑血管系统中保持神经血管与认知活动的耦合。

背景：高空旅居挑战了大脑的血流调节，这可能导致认知功能障碍。神经血管耦合（NVC）描述了增加流向大脑工作区域的血流的能力。尚不清楚高原对经历认知激活的额叶区域NVC的影响，但可能与高原低氧时的执行功能有关。这项研究试图通过测量大脑前动脉（ACA）和大脑中动脉（MCA）对持续认知活动的血流动力学反应，来研究上升到非常高的海拔对NVC的影响。