Adenoviruses (AdVs) are major contributors to clinical illnesses. Novel human and animal AdVs continue to be identified and characterized. Comparative analyses using bioinformatic methods and Omics-based technologies allow insights into how these human pathogens have emerged and their potential for host cross-species transmission. Systematic review of literature published across ProQuest, Pubmed, and Web of Science databases for evidence of adenoviral zoonotic potential identified 589 citations. After removing duplicates, 327 citations were screened for relevance; of which, 74 articles received full-text reviews. Among these, 24 were included here, of which 16 demonstrated evidence of zoonotic transmission of AdVs. These documented instances of AdV crossing host species barriers between humans and non-human primate, bat, feline, swine, canine, ovine, and caprine. Eight studies sought to but did not find evidence of zoonosis. The findings demonstrate substantial evidence suggesting AdVs have previously and will continue crossing host species barriers. These have human health consequences both in terms of novel pathogen emergence and epidemic outbreaks, and of appropriate and safe use of non-human adenoviruses for therapeutics. As routine human clinical diagnostics may miss a novel cross-species adenovirus infection in humans, next generation sequencing or panspecies molecular diagnostics may be necessary to detect such incursions.

中文翻译：

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腺病毒是人畜共患病吗？对证据的系统审查。

腺病毒（AdV）是导致临床疾病的主要因素。新型人类和动物AdV继续得到鉴定和表征。使用生物信息学方法和基于Omics的技术进行的比较分析可以洞悉这些人类病原体如何出现以及它们在宿主跨物种传播中的潜力。系统地审查了通过ProQuest，Pubmed和Web of Science数据库发布的文献，以发现腺病毒人畜共患病潜力的证据，共发现589条引用文献。删除重复项后，对327篇相关文献进行了筛选；其中74条文章获得了全文评论。其中，这里包括24个，其中16个证明了AdV的人畜共患性传播的证据。这些已记录的AdV跨越人类与非人类灵长类，蝙蝠，猫，猪，犬，绵羊和山羊。八项研究试图但没有发现人畜共患病的证据。研究结果表明，有充分的证据表明AdV以前已经并将继续越过宿主物种的壁垒。这些在新的病原体出现和流行病爆发方面以及对非人类腺病毒适当安全使用进行治疗方面均对人类健康造成影响。由于常规的人类临床诊断可能会错过人类中新型的跨物种腺病毒感染，因此下一代测序或全物种分子诊断可能对于检测此类入侵至关重要。这些在新的病原体出现和流行病爆发方面以及对非人类腺病毒进行适当和安全使用进行治疗方面均对人类健康造成影响。由于常规的人类临床诊断可能会错过人类中新型的跨物种腺病毒感染，因此下一代测序或全物种分子诊断可能对于检测此类入侵至关重要。这些在新的病原体出现和流行病爆发方面以及对非人类腺病毒进行适当和安全使用进行治疗方面均对人类健康造成影响。由于常规的人类临床诊断可能会错过人类中新型的跨物种腺病毒感染，因此下一代测序或全物种分子诊断可能对于检测此类入侵至关重要。