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Role of zinc and copper ions in the pathogenetic mechanisms of traumatic brain injury and Alzheimer’s disease
Reviews in the Neurosciences ( IF 4.1 ) Pub Date : 2019-11-20 , DOI: 10.1515/revneuro-2019-0052
Nickolay K Isaev 1, 2 , Elena V Stelmashook 2 , Elisaveta E Genrikhs 2
Affiliation  

The disruption of homeostasis of zinc (Zn2+) and copper (Cu2+) ions in the central nervous system is involved in the pathogenesis of many neurodegenerative diseases, such as amyotrophic lateral sclerosis, Wilson’s, Creutzfeldt-Jakob, Parkinson’s, and Alzheimer’s diseases (AD), and traumatic brain injury (TBI). The last two pathological conditions of the brain are the most common; moreover, it is possible that TBI is a risk factor for the development of AD. Disruptions of Zn2+and Cu2+homeostasis play an important role in the mechanisms of pathogenesis of both TBI and AD. This review attempts to summarize and systematize the currently available research data on this issue. The neurocytotoxicity of Cu2+and Zn2+, the synergism of the toxic effect of calcium and Zn2+ions on the mitochondria of neurons, and the interaction of Zn2+and Cu2+with β-amyloid (Abeta) and tau protein are considered.

中文翻译:

锌和铜离子在脑外伤和阿尔茨海默病发病机制中的作用

锌稳态的破坏(Zn2+) 和铜 (Cu2+) 中枢神经系统中的离子参与许多神经退行性疾病的发病机制,例如肌萎缩性侧索硬化症、威尔逊氏症、克雅氏症、帕金森氏症和阿尔茨海默氏症 (AD) 以及创伤性脑损伤 (TBI)。大脑的最后两种病理状况是最常见的;此外,TBI 可能是 AD 发展的风险因素。锌的破坏2+和铜2+体内平衡在 TBI 和 AD 的发病机制中起重要作用。这篇综述试图总结和系统化目前关于这个问题的研究数据。铜的神经细胞毒性2+和锌2+, 钙和锌的毒性作用的协同作用2+神经元线粒体上的离子和锌的相互作用2+和铜2+β-淀粉样蛋白 (Abeta) 和 tau 蛋白被考虑在内。
更新日期:2019-11-20
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