A new flavonoid, macatanarin D (1), together with five known stilbenes (2-6), was isolated from fruit glandular trichomes of Macaranga tanarius. Their structures were elucidated on the basis of spectroscopic methods and through comparison with data reported in the literature. All isolated compounds were evaluated for their cytotoxic activities against KB and MCF-7 cell lines. Compounds 3, 4, and 5 showed the strongest activities against both cell lines with IC50 values in the range of 0.03–0.12 μM, and compound 2 only showed a significant cytotoxicity against KB cell line (IC50 = 0.26 μM) and a moderate cytotoxicity against MCF-7 (IC50 = 10.4 μM). Compounds 1 and 6 showed weak cytotoxic activities against KB cell line with IC50 values of 29.3 and 24.7 μM, respectively.

中文翻译：

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来自马卡兰加果（Macaranga tanarius）的果实腺毛的细胞毒性酚类化合物。

从Macaranga tanarius的果实腺毛体中分离出一种新的类黄酮，Macatanarin D（1）和五个已知的对苯二酚（2-6）。通过光谱方法并与文献报道的数据进行比较，阐明了它们的结构。评价所有分离的化合物对KB和MCF-7细胞系的细胞毒性活性。化合物3、4和5对两种细胞系均表现出最强的活性，IC50值为0.03-0.12μM，化合物2仅对KB细胞系表现出显着的细胞毒性（IC50 = 0.26μM），对KB细胞系具有中等的细胞毒性MCF-7（IC50 = 10.4μM）。化合物1和6对KB细胞系的细胞毒性较弱，IC50值分别为29.3和24.7μM。