We in this study investigated the role of imatinib-upregulated lncRNA (IUR) in prostate carcinoma (PC). We observed that IUR was downregulated in PC, and its expression levels decreased with the increase of clinical stages. In PC tissues, microRNA (miR)-200 was positively, while ZEB1 was inversely correlated with IUR. In PC cells, IUR and miR-200 overexpression mediated the downregulated ZEB1. IUR overexpression mediated the upregulation of miR-200, while IUR expression was not significantly affected by miR-200 overexpression. Cell invasion and migration analysis showed that IUR and miR-200 overexpression resulted in decreased invasion and migration rates. ZEB1 overexpression played an opposite role and attenuated the effects of IUR and miR-200 overexpression. Therefore, IUR can downregulate ZEB1 by upregulating miR-200 to inhibit PC cell invasion and migration.

中文翻译：

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LncRNA IUR通过上调miR-200抑制前列腺癌而下调ZEB1。

我们在这项研究中调查了伊马替尼上调的lncRNA（IUR）在前列腺癌（PC）中的作用。我们观察到IUR在PC中被下调，并且其表达水平随着临床阶段的增加而降低。在PC组织中，microRNA（miR）-200呈阳性，而ZEB1与IUR呈负相关。在PC细胞中，IUR和miR-200的过度表达介导了ZEB1的下调。IUR的过度表达介导了miR-200的上调，而IUR的表达不受miR-200的过度表达的影响。细胞侵袭和迁移分析表明，IUR和miR-200过表达导致侵袭和迁移率降低。ZEB1过表达起相反的作用，并减弱了IUR和miR-200过表达的作用。因此，