To evaluate the influence of sex and gender on clinical characteristics and survival in multiple system atrophy (MSA), we reviewed MSA patients with autonomic testing 1998-2012. Of 685 patients, 52% were male. Median survival overall was 7.3 years for males, 7.6 years for females. Survival from diagnosis was 2.9 years in males, 3.8 years in females. Females were more likely to initially manifest motor symptoms. Males were more likely to have orthostatic intolerance and early catheterization. In conclusion, our data show longer survival from diagnosis in females and slight overall survival benefit which may be related to initial motor manifestations.

中文翻译：

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性别和性别影响多系统萎缩的症状表现和生存

为了评估性别对多系统萎缩 (MSA) 临床特征和存活率的影响，我们回顾了 1998-2012 年进行自主神经测试的 MSA 患者。在 685 名患者中，52% 是男性。男性的中位总生存期为 7.3 年，女性为 7.6 年。男性确诊后生存期为 2.9 年，女性为 3.8 年。女性更可能最初表现出运动症状。男性更可能有直立不耐受和早期导管插入术。总而言之，我们的数据显示，女性诊断后的生存期更长，总体生存率略有提高，这可能与最初的运动表现有关。