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Analysis of Resistance Gene Prevalence in Whole-Genome Sequenced Enterobacteriales from Brazil.
Microbial Drug Resistance ( IF 2.6 ) Pub Date : 2020-06-08 , DOI: 10.1089/mdr.2019.0370
Felipe Pinheiro Vilela 1 , Juliana Pfrimer Falcão 1 , Fábio Campioni 1
Affiliation  

Enterobacteriales is an order of bacteria responsible for community and hospital-acquired infections related to high rates of antimicrobial resistance and increased treatment costs, morbidity, and mortality globally. The aims of this study were to analyze the frequency of the resistance genes detected and distribution over the years and sources of isolation in sequenced Enterobacteriales strains isolated in Brazil and available at the Pathogen Detection website. The presence of resistance genes was analyzed in 1,507 whole-genome sequenced strains of 19 Enterobacteriales species. A total of 58.0% of the strains presented resistance genes to at least one antimicrobial class and 684 strains presented a multidrug-resistant (MDR) profile. Resistance genes to 14 classes of antimicrobials were detected. Aminoglycosides presented the most prevalent and diverse resistance genes, while the sulfonamide resistance gene, sul2, was the most prevalent among the strains studied. The presence of resistance genes from 14 different antimicrobial classes, the high levels of MDR strains, and the detection of genes related to clinical and veterinary-used drugs reinforce the necessity of more efficient control measures. Moreover, it warns for the necessity of the rational use of antimicrobials in veterinary and clinical situations in Brazil, since contaminated food may act as a vehicle for human infections.

中文翻译:

巴西全基因组测序肠杆菌中抗性基因发生率的分析。

肠杆菌是导致社区和医院获得性感染的细菌,与高耐药率以及全球治疗费用,发病率和死亡率的增加有关。这项研究的目的是分析多年来在巴西分离的,可在“病原体检测”网站上找到的测序肠杆菌菌株中检测到的耐药基因的频率和分布以及分离来源。在19个肠杆菌的1,507个全基因组测序菌株中分析了抗性基因的存在种类。共有58.0%的菌株表现出对至少一种抗菌素类的抗性基因,而684株表现出多药耐药性(MDR)。检测到对14种抗菌素的耐药基因。氨基糖苷类化合物表现出最普遍和最多样化的抗性基因,而磺酰胺类抗性基因sul2,是所研究菌株中最普遍的。来自14种不同抗菌素类的耐药基因的存在,高水平的MDR菌株以及与临床和兽用药物有关的基因的检测加强了采取更有效控制措施的必要性。此外,它警告说在巴西的兽医和临床情况中必须合理使用抗菌剂,因为受污染的食物可能会成为人类感染的媒介。
更新日期:2020-06-08
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