The social acceptability of germline genome editing (GGE) depends on its perceived safety, as well as respect for reproductive autonomy. However, it is doubtful that prospective parents sufficiently understand the risks of GGE. In the future, the use of GGE in specific situations seems plausible, as it offers couples potential means to safeguard genetically related future children from a serious disease and overcome infertility due to a gene mutation. Should GGE fail, however, some couples may be obliged to abort affected fetuses, or give birth to adversely affected children, which would be a tragedy. Some children might develop diseases later in life due to overlooked off-target mutations. Compounding this, some parents are unlikely to inform their offspring about the details of conception, hampering necessary follow-up. Prospective parents, scientists and policy makers should carefully discuss the safety implications of GGE for genetically related future children.

中文翻译：

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父母认为，与遗传相关的“未来”儿童的生殖细胞基因组编辑的安全性。

种系基因组编辑（GGE）的社会可接受性取决于其感知的安全性以及对生殖自主性的尊重。但是，令人怀疑的是，准父母是否充分了解GGE的风险。将来，在特定情况下使用GGE似乎是合理的，因为它为夫妇提供了潜在的手段，可以保护遗传相关的未来儿童免受严重疾病的困扰，并克服由于基因突变而导致的不育症。但是，如果GGE失败，某些夫妇可能不得不流产受影响的胎儿，或生下受到不利影响的孩子，这将是一场悲剧。由于忽略了脱靶突变，有些孩子可能会在晚年患上疾病。更为严重的是，一些父母不太可能将其受孕细节告知其后代，从而妨碍了必要的随访。准父母