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Attitudes of Asian Parkinson patients towards brain donation.
Cell and Tissue Banking ( IF 1.5 ) Pub Date : 2019-10-03 , DOI: 10.1007/s10561-019-09788-1
Shazma Khan 1, 2 , Joel Y J Foo 3 , Nicole S Y Chia 2, 3 , Sherwin J U Agustin 3 , Shermyn X M Neo 1, 2 , Kay-Yaw Tay 1, 2 , Wing-Lok Au 1, 2 , Adeline S L Ng 1, 2 , Louis C S Tan 1, 2, 3
Affiliation  

Histopathological examination of brain tissue is required for better understanding of neurodegenerative conditions such as Parkinson’s disease and related disorders. However, patient willingness remains the greatest hurdle hampering participation in brain donation for research. While there is extensive research being conducted on the subject in West, to the best of our knowledge, there are no studies done in this regard in Asia. This cross-sectional survey was conducted on 105 Parkinson’s disease patients to assess their knowledge, beliefs and attitude towards brain donation in an Asian population. The majority of the participants (78%) acknowledged the importance of donation of brain for research, and 70% believed that their donated brain samples would be handled professionally. Fifty percent participants were willing to consider donating their brain for research. Motivating factors for brain donation included altruism (87%) and contribution to advance medical knowledge (80%). Common reasons for unwillingness towards brain donation were stress for family (30%), disfigurement of body (25%), and having a conservative mindset (23%). About one-third of the participants preferred to be approached for brain donation after their first clinic visit. Most patients preferred either their treating neurologists (66%) or research staff (18%) to discuss brain donation with. Participation for brain donation may be increased further with greater patient and public education to overcome misconceptions and change mindsets.

中文翻译:

亚洲帕金森氏症患者对脑捐赠的态度。

为了更好地了解神经退行性疾病(如帕金森氏病和相关疾病),需要对脑组织进行组织病理学检查。但是,患者的意愿仍然是阻碍参与大脑捐赠进行研究的最大障碍。据我们所知,尽管在西方已经对该主题进行了广泛的研究,但在亚洲没有进行过这方面的研究。这项横断面调查是针对105位帕金森氏病患者进行的,旨在评估他们在亚洲人群中对大脑捐献的知识,信念和态度。大多数参与者(78%)承认捐赠大脑对于研究非常重要,而70%的参与者认为捐赠的大脑样本将得到专业处理。50%的参与者愿意考虑捐献大脑进行研究。捐赠大脑的动机包括利他(87%)和促进医学知识的贡献(80%)。不愿捐献大脑的常见原因包括家庭压力(30%),身体残废(25%)和保守的心态(23%)。大约三分之一的参与者在首次访问诊所后更愿意接受大脑捐赠。大多数患者更愿意与他们的治疗神经科医生(66%)或研究人员(18%)进行脑捐赠的讨论。通过更多的患者和公众教育来克服误解并改变思维方式,可以进一步增加对大脑捐赠的参与。捐赠大脑的动机包括利他(87%)和促进医学知识的贡献(80%)。不愿捐献大脑的常见原因包括家庭压力(30%),身体残废(25%)和保守的心态(23%)。大约三分之一的参与者在首次访问诊所后更愿意接受大脑捐赠。大多数患者更愿意与他们的治疗神经科医生(66%)或研究人员(18%)进行脑捐赠的讨论。通过更多的患者和公众教育来克服误解并改变思维方式,可以进一步增加对大脑捐赠的参与。捐赠大脑的动机包括利他(87%)和促进医学知识的贡献(80%)。不愿捐献大脑的常见原因包括家庭压力(30%),身体残废(25%)和保守的心态(23%)。大约三分之一的参与者在首次访问诊所后更愿意接受大脑捐赠。大多数患者更愿意与他们的治疗神经科医生(66%)或研究人员(18%)进行脑捐赠的讨论。通过更多的患者和公众教育来克服误解并改变思维方式,可以进一步增加对大脑捐赠的参与。大约三分之一的参与者在首次访问诊所后更愿意接受大脑捐赠。大多数患者更愿意与他们的治疗神经科医生(66%)或研究人员(18%)进行脑捐赠的讨论。通过更多的患者和公众教育来克服误解并改变思维方式,可以进一步增加对大脑捐赠的参与。大约三分之一的参与者在首次访问诊所后更愿意接受大脑捐赠。大多数患者更愿意与他们的治疗神经科医生(66%)或研究人员(18%)进行脑捐赠的讨论。通过更多的患者和公众教育来克服误解并改变思维方式,可以进一步增加对大脑捐赠的参与。
更新日期:2019-10-03
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