The foodborne pathogen Listeria monocytogenes can modulate its transcriptome and proteome to ensure its survival during transmission through vastly differing environmental conditions. While L. monocytogenes utilizes a large array of regulators to achieve survival and growth in different intra- and extrahost environments, the alternative sigma factor σB and the transcriptional activator of virulence genes protein PrfA are two key transcriptional regulators essential for responding to environmental stress conditions and for host infection. Importantly, emerging evidence suggests that the shift from extrahost environments to the host gastrointestinal tract and, subsequently, to intracellular environments requires regulatory interplay between σB and PrfA at transcriptional, posttranscriptional, and protein activity levels. Here, we review the current evidence for cross talk and interplay between σB and PrfA and their respective regulons and highlight the plasticity of σB and PrfA cross talk and the role of this cross talk in facilitating successful transition of L. monocytogenes from diverse extrahost to diverse extra- and intracellular host environments.

中文翻译：

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单核细胞增生李斯特菌中SigB和PrfA之间的串扰促进细胞外和细胞内环境之间的转换。

食源性单核细胞增生李斯特氏菌可以调节其转录组和蛋白质组，以确保其在通过截然不同的环境条件传播过程中的存活。单核细胞增生李斯特氏菌利用多种调节剂在不同的宿主内和宿主外环境中存活和生长，而替代的sigma因子σB和毒力基因蛋白PrfA的转录激活剂是对环境压力条件和抗性至关重要的两个关键转录调节剂。用于宿主感染。重要的是，越来越多的证据表明，从宿主外环境到宿主胃肠道，再到细胞内环境的转变，需要σB和PrfA在转录，转录后和蛋白质活性水平上的调节相互作用。这里，