Terminally differentiated keratinocytes acquire corneocyte protein envelopes (CPE) complexed with corneocyte lipid envelopes (CLE). These two structural components of the corneocyte envelopes (CEs) undergo maturation by gaining in hydrophobicity, rigidity and surface area. Linoleoyl acylceramides are processed by 12R‐lipoxygenase (12R‐LOX) and other enzymes before transglutaminase (TG) attaches ω‐hydroxyceramides to involucrin in the CPE. Concurrently, structural proteins are cross‐linked by TG that has been activated by cathepsin D (CathD).

中文翻译：

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12R-脂氧合酶和转谷氨酰胺酶活性在角质细胞包膜水合依赖性离体成熟中的重要性。

终末分化的角质形成细胞获得与角质细胞脂质包膜 (CLE) 复合的角质细胞蛋白包膜 (CPE)。角质细胞包膜 (CEs) 的这两种结构成分通过增加疏水性、刚性和表面积而成熟。在转谷氨酰胺酶 (TG) 将 ω-羟基神经酰胺连接到 CPE 中的外皮蛋白之前，亚油酰酰基神经酰胺由 12R-脂氧合酶 (12R-LOX) 和其他酶加工。同时，结构蛋白被组织蛋白酶 D (CathD) 激活的 TG 交联。