Replicative senescence, which is induced by telomere shortening, underlies the loss of regeneration capacity of organs and is ultimately detrimental to the organism. At the same time, it is required to protect organisms from unlimited cell proliferation that may arise from numerous stimuli or deregulations. One important feature of replicative senescence is its high level of heterogeneity and asynchrony, which promote genome instability and senescence escape. Characterizing this heterogeneity and investigating its sources are thus critical to understanding the robustness of replicative senescence. Here we review the different aspects of senescence driven by telomere attrition that are subject to variation in Saccharomyces cerevisiae, the current understanding of the molecular processes at play, and the consequences of heterogeneity in replicative senescence.

中文翻译：

---

复制衰老中的多种异质性。

端粒缩短引起的复制性衰老是器官再生能力丧失的基础，并最终对生物体有害。同时，需要保护有机体免受可能因众多刺激或放松调控而引起的无限细胞增殖。复制性衰老的一个重要特征是其高度的异质性和异步性，可促进基因组不稳定和衰老逃逸。因此，表征这种异质性并研究其来源对于理解复制衰老的稳健性至关重要。在这里，我们回顾了由端粒磨损引起的衰老的不同方面，这些方面可能会受到酿酒酵母的变化，当前对分子过程的理解，