Campylobacter jejuniis an important zoonotic pathogen recently designated a serious antimicrobial resistant (AR) threat. While most patients withC. jejuniexperience hemorrhagic colitis, serious autoimmune conditions can follow including inflammatory bowel disease (IBD) and the acute neuropathy Guillain Barré Syndrome (GBS). This review examines inter-relationships among factors mediatingC. jejunidiarrheal versus autoimmune disease especially ARC. jejuniand microbiome shifts. Because both susceptible and ARC. jejuniare acquired from animals or their products, we consider their role in harboring strains. Inter-relationships among factors mediatingC. jejunicolonization, diarrheal and autoimmune disease includeC. jejunivirulence factors and AR, the enteric microbiome, and host responses. Because ARC. jejunihave been suggested to affect the severity of disease, length of infections and propensity to develop GBS, it is important to understand how these interactions occur when strains are under selection by antimicrobials. More work is needed to elucidate host–pathogen interactions of ARC. jejunicompared with susceptible strains and how ARC. jejuniare maintained and evolve in animal reservoirs and the extent of transmission to humans. These knowledge gaps impair the development of effective strategies to prevent the emergence of ARC. jejuniin reservoir species and human populations.

中文翻译：

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抗生素耐药性 (AR) 和微生物群变化对空肠弯曲杆菌介导的疾病的影响

空肠弯曲杆菌是一种重要的人畜共患病病原体，最近被指定为严重的抗菌素耐药性 (AR) 威胁。虽然大多数患者空肠弯曲杆菌经历出血性结肠炎，可能会出现严重的自身免疫性疾病，包括炎症性肠病 (IBD) 和急性神经病格林巴利综合征 (GBS)。本综述探讨了中介因素之间的相互关系空肠弯曲杆菌腹泻与自身免疫性疾病，尤其是 AR空肠弯曲杆菌和微生物组的变化。因为易感和 AR空肠弯曲杆菌是从动物或其产品中获得的，我们认为它们在携带菌株中的作用。中介因素之间的相互关系空肠弯曲杆菌定植、腹泻和自身免疫性疾病包括空肠弯曲杆菌毒力因子和 AR、肠道微生物组和宿主反应。因为增强现实空肠弯曲杆菌已被建议影响疾病的严重程度、感染的长度和发展 GBS 的倾向，重要的是要了解当菌株被抗菌素选择时这些相互作用是如何发生的。需要更多的工作来阐明 AR 的宿主-病原体相互作用空肠弯曲杆菌与易感菌株相比，AR 如何空肠弯曲杆菌在动物宿主中维持和进化以及传播给人类的程度。这些知识差距阻碍了有效策略的发展，以防止 AR 的出现空肠弯曲杆菌在水库物种和人​​口中。