Objective: The objective of the study was to explore the intestinal flora in patients with dual antiplatelet therapy.Method: We collected fresh stool specimens from 10 patients receiving dual antiplatelet therapy and 10 healthy people as control group. Then, we extracted faecal DNA, amplified 16 s rNDA V3-V4 area, and applied Illumina Miseq to analyse the structure of intestinal flora.Result: At class level, DAPT group show higher abundance of class Bacilli and lower abundance of class Erysipelotrichia. At order level, the abundance of order Lactobacillales in DAPT group is higher (p < .05), while the abundance of order Erysipelotrichales is lower in DAPT group (p < .05). At family level, the abundance of family Streptococcaceae and family Lactobacillaceae in DAPT group is higher (p < .05), while the abundance of family Acidaminococcaceae and family Erysipelotrichaceae is lower in DAPT group (p < .05). At genus level, the abundance of genus Streptococcus and genus Klebsiella in DAPT group is higher (p < .05), while the abundance of genus Blautia, genus Phascolarctobacterium and genus Megamonas is lower in DAPT group (p < .05).Conclusion: Taking aspirin and clopidogrel will not cause a change in the biodiversity of intestinal flora. There are significant differences in the intestinal flora of DAPT group compared with the control group at class, order, family and genus level.

中文翻译：

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双重抗血小板治疗患者肠道菌群特征的研究

目的：本研究的目的是探讨双重抗血小板治疗患者的肠道菌群。方法：我们收集10例接受双重抗血小板治疗的患者和10名健康人作为对照组的新鲜粪便标本。然后，我们提取粪便DNA，扩增16 s rNDA V3-V4区，应用Illumina Miseq分析肠道菌群结构。结果：在类水平上，DAPT组显示出较高的Bacilli类丰度和较低的Erysipelotrichia类丰度。在订单水平上，DAPT 组中乳酸杆菌目的丰度较高（p < .05），而 DAPT 组中丹毒杆菌目的丰度较低（p < .05）。在家庭层面，DAPT 组中链球菌科和乳杆菌科的丰度较高（p < .05），而在 DAPT 组中，Acidaminococcaceae 和 Erysipelotrichaceae 的丰度较低（p < .05）。在属水平上，DAPT组中链球菌属和克雷伯氏菌属的丰度较高（p < .05），而DAPT组中Blautia属、Phascolarctobacterium和Megamonas属的丰度较低（p < .05）。 结论：服用阿司匹林和氯吡格雷不会引起肠道菌群生物多样性的变化。DAPT组肠道菌群与对照组相比，在纲、目、科、属水平上均存在显着差异。DAPT组中Phascolarctobacterium属和Megamonas属较低(p < .05)。结论：服用阿司匹林和氯吡格雷不会引起肠道菌群生物多样性的变化。DAPT组肠道菌群与对照组相比，在纲、目、科、属水平上均存在显着差异。DAPT组中Phascolarctobacterium属和Megamonas属较低(p < .05)。结论：服用阿司匹林和氯吡格雷不会引起肠道菌群生物多样性的变化。DAPT组肠道菌群与对照组相比，在纲、目、科、属水平上均存在显着差异。