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Occupational swine exposure and Hepatitis E virus, Leptospira, Ascaris suum seropositivity and MRSA colonization in Austrian veterinarians, 2017-2018-A cross-sectional study.
Zoonoses and Public Health ( IF 2.4 ) Pub Date : 2019-08-16 , DOI: 10.1111/zph.12633
Karin Taus 1, 2 , Friedrich Schmoll 3 , Ziad El-Khatib 1, 4 , Herbert Auer 5 , Heidemarie Holzmann 6 , Stephan Aberle 6 , Shiva Pekard-Amenitsch 7 , Stefanie Monschein 7 , Tatjana Sattler 3, 8 , Romana Steinparzer 3 , Franz Allerberger 1 , Daniela Schmid 1
Affiliation  

We investigated the prevalence of Hepatitis E Virus (HEV), Leptospira and Ascaris suum (A. suum) seropositivity, and of nasal methicillin‐resistant Staphylococcus aureus (MRSA) colonization among Austrian practising veterinarians, and assessed the association with occupational swine livestock exposure. The 261 participants completed a questionnaire on demographics, intensity of occupational swine livestock contact and glove use during handling animals and their secretions. Participants' blood samples were tested for HEV, Leptospira and A. suum seropositivity and nasal swabs cultured for MRSA. We compared swine veterinarians (defined as >3 swine livestock visits/week) to non‐swine veterinarians (≤3 swine livestock visits/week) with regard to the outcomes through calculating prevalence ratio (PR) and 95% confidence interval (CI). Furthermore, the relationship between occupational swine livestock contact and the study outcomes was examined by age (</≥55 years) and glove usage. The prevalence of nasal MRSA colonization was 13.4% (95% CI: 9.3–17.6), of HEV seropositivity 20.8% (95% CI: 15.8–25.7) and A. suum seropositivity 44% (95% CI: 37.7–50.2). The highest anti‐leptospiral antibodies titres were 1:200 (L. hebdomadis) and 1:100 (L. autumnalis, L. caicola) found in three non‐swine veterinarians. Compared to non‐swine veterinarians, swine veterinarians were 1.9 (95% CI: 1.0–3.4) and 1.5 (95%CI: 1.0–2.3) times more likely HEV seropositive and A. suum seropositive, respectively, and 4.8 (95%CI: 2.5; 9.3) times more likely nasally colonized with MRSA. Among glove‐using veterinarians, occupational swine contact was no longer a determinant for HEV seropositivity (PR 1.6; 95% CI: 0.8–2.9). Similar was found for A. suum seropositivity, which was no longer associated with occupational swine livestock contact in the subgroup of glove using, ≥55‐year‐old veterinarians (PR: 1.07; 95% CI: 0.4–3.3). Our findings indicate that >3 occupational swine livestock visits per week is associated with HEV and A. suum seropositivity and nasal MRSA colonization and that glove use may play a putative preventive role in acquiring HEV and A. suum. Further analytical epidemiological studies have to prove the causality of these associations.

中文翻译:

2017-2018年,奥地利猪的职业性猪暴露和戊型肝炎病毒,钩端螺旋体,猪A虫的血清阳性和MRSA定殖。

我们调查了奥地利执业兽医中戊型肝炎病毒(HEV),钩端螺旋体AA. suum)血清阳性的流行率以及耐甲氧西林金黄色葡萄球菌(MRSA)的鼻定植率,并评估了其与职业性猪家畜接触的相关性。261名参与者完成了一份关于人口统计学,职业性猪与牲畜接触的强度以及在处理动物及其分泌物时使用手套的问卷。对参与者的血液样本进行了HEV,钩端螺旋体猪链球菌的检测血清阳性和鼻拭子培养的MRSA。通过计算患病率(PR)和95%置信区间(CI),我们比较了猪兽医(定义为每周> 3的猪牲畜探访)和非猪兽医(≤3猪/每周)的结局。此外,通过年龄(</≥55岁)和手套的使用来检查职业猪家畜接触与研究结果之间的关系。鼻MRSA菌落的患病率为13.4%(95%CI:9.3-17.6),HEV血清阳性率为20.8%(95%CI:15.8-25.7)和A. suum血清阳性率为44%(95%CI:37.7-50.2)。最高的抗钩端螺旋体抗体滴度为1:200(Hebdomadis)和1:100(L. autumnalis,L. caicola))在三名非猪兽医中发现。与非猪兽医相比,HEV血清阳性和猪链球菌血清阳性的可能性分别高1.9(95%CI:1.0–3.4)和1.5(95%CI:1.0–2.3)倍和4.8(95%CI) :2.5; 9.3)的患者在鼻部定植MRSA的可能性更高。在使用手套的兽医中,职业猪的接触不再是戊型肝炎病毒阳性的决定因素(PR 1.6; 95%CI:0.8-2.9)。su。suum的血清阳性反应也发现了类似情况,不再与≥55岁的兽医使用的手套亚组中的职业性猪牲畜接触有关(PR:1.07; 95%CI:0.4–3.3)。我们的研究结果表明,每周> 3次职业猪家畜探访与戊型肝炎病毒猪链球菌相关血清阳性和鼻MRSA定殖以及戴手套可能对获得戊型肝炎病毒猪链球菌起到预防作用。进一步的流行病学分析研究必须证明这些关联的因果关系。
更新日期:2019-08-16
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