To investigate the effects of Gastrodia elata Blume (GEB) and 4-hydroxybenzyl alcohol (HBA) on brain damage, GEB or HBA was administered orally for 14 days before middle cerebral artery occlusion (MCAO). After 24 h reperfusion, the proportion of circling was significantly reduced in the GEB (79%) or HBA (69%) group compared to the MCAO group (100%) in the corner test, and the removal time in the adhesive removal test was significantly decreased in the GEB (117 ± 21.0 s) and HBA (101 ± 20.9 s) groups compared to the MCAO group (161 ± 12.6 s). GEB treatment significantly reduced infarct volume compared to the MCAO group. In the GEB and HBA group, necrosis of nerve cells in hippocampus and cortex, expressions of TNF-α and TUNEL positive cells were significantly reduced compared to the MCAO group. These results suggest that GEB and HBA prevents brain damage by anti-inflammatory and anti-apoptotic effects.

中文翻译：

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天麻提取物对大鼠大脑中动脉闭塞的保护作用。

为了研究天麻蓝光（GEB）和4-羟基苄醇（HBA）对脑损伤的影响，在大脑中动脉闭塞（MCAO）之前，口服GEB或HBA 14天。再灌注24小时后，在角落测试中，与MCAO组（100％）相比，GEB（79％）或HBA（69％）组中的盘旋比例显着降低，并且去除时间为与MCAO组（161±12.6 s）相比，GEB（117±21.0 s）和HBA（101±20.9 s）组显着降低。与MCAO组相比，GEB治疗显着减少了梗塞体积。与MCAO组相比，GEB和HBA组海马和皮层神经细胞坏死，TNF-α和TUNEL阳性细胞的表达明显降低。