Mixed culture anaerobic processes are important to environmental systems, including the global carbon cycle, and industrial and environmental biotechnology. Mixed culture metabolic modelling (MM) is an essential tool to analyse these systems. MM predicts microbial function based on knowledge or assumption of cellular metabolism. It may be developed based on observations at the process level - biochemical process modelling (BPM) or fundamental knowledge of the cell being modelled - cellular level modelling (CLM). There is a substantial gap between these two fields, with BPM not considering genetic constraints, particularly where this may be important to interspecies interactions (e.g. amino acid transfer), and CLM commonly not considering mass transfer principles, such as advection/diffusion/migration. No unified approach is useful for all applications, but there is an increasing need to consider genetic information and constraints in developing BPM, and translate BPM principles (including mass-transfer and inorganic chemistry) for application to CLM.

中文翻译：

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混合培养厌氧微生物过程的代谢建模。

混合培养厌氧过程对环境系统（包括全球碳循环以及工业和环境生物技术）非常重要。混合培养代谢模型（MM）是分析这些系统的基本工具。MM根据细胞代谢的知识或假设来预测微生物功能。它可以基于过程级别的观察结果-生化过程建模（BPM）或要建模的细胞的基本知识-细胞水平建模（CLM）来开发。这两个领域之间存在很大差距，BPM不考虑遗传限制，特别是在对种间相互作用（例如氨基酸转移）可能很重要的地方，而CLM通常不考虑传质原理，例如对流/扩散/迁移。