Fully grown mammalian oocytes maintain a prophase I germinal-vesicle stage arrest in the ovary for extended periods before a luteinizing hormone surge induces entry into the first meiotic division. Cdh1 is an activator of the anaphase-promoting complex (APC) and APCcdh1 is normally restricted to late M to early G1 phases of the cell cycle. Here, we find that APCcdh1 is active in mouse oocytes and is necessary to maintain prophase arrest.

中文翻译：

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小鼠卵母细胞中的APCcdh1活性阻止其进入第一个减数分裂。

成熟的卵母细胞在促黄体激素激增诱导进入第一个减数分裂之前，在卵巢中保持了前期I阶段的生殖-囊泡阶段停滞期。Cdh1是后期促进复合物（APC）的激活剂，并且APCcdh1通常限于细胞周期的M晚期至G1早期。在这里，我们发现APCcdh1在小鼠卵母细胞中活跃，是维持前期停滞所必需的。