Degradation rate of hyaluronic acid to prolong its stability in vivo would be beneficial. We investigated a potential solution for prolonging the stability of hyaluronic acid within the body. We focused on decreasing the swelling ratio to slow the degradation rate of hyaluronic acid by insolubilizing sodium hyaluronate without using potentially harmful substances such as crosslinkers or modifiers. Hyaluronic acid formulations were created with three different swelling ratios and time-dependent morphological changes in hyaluronic acid formulations and were scored based on each swelling ratio. In vivo degradation was modeled in simulated body fluid and the extent of decay of test membranes were monitored over time. Results showed that, by adjusting the swelling ratio, the degradation rate of hyaluronic acid formulation could be controlled. Our research could lead to improvements in many products, not only preventive materials for postoperative adhesions, but also pharmaceutical products such as osteoarthritis treatments and cosmetic medicines.

中文翻译：

---

阐明了降解速率受控的不溶性透明质酸制剂中随时间变化的降解过程。

透明质酸的降解速率以延长其在体内的稳定性将是有益的。我们研究了延长玻尿酸在体内稳定性的潜在解决方案。我们致力于降低溶胀率，通过不溶解透明质酸钠来减缓透明质酸的降解速度，而不使用可能有害的物质，例如交联剂或改性剂。透明质酸制剂的创建具有三种不同的溶胀率和透明质酸制剂中随时间变化的形态变化，并根据每种溶胀率进行评分。在模拟的体液中模拟体内降解，并随时间监测测试膜的降解程度。结果表明，通过调节溶胀率，可以控制透明质酸制剂的降解率。