RPGeNet offers researchers a user-friendly queriable tool to visualize the interactome network of visual disorder genes, thus enabling the identification of new potential causative genes and the assignment of novel candidates to specific retinal or cellular pathways. This can be highly relevant for clinical applications as retinal dystrophies affect 1:3000 people worldwide, and the causative genes are still unknown for 30% of the patients. RPGeNet is a refined interaction network interface that limits its skeleton network to the shortest paths between each and every known causative gene of inherited syndromic and non-syndromic retinal dystrophies. RPGeNet integrates interaction information from STRING, BioGRID and PPaxe, along with retina-specific expression data and associated genetic variants, over a Cytoscape.js web interface. For the new version, RPGeNet v2.0, the database engine was migrated to Neo4j graph database manager, which speeds up the initial queries and can handle whole interactome data for new ways to query the network. Further, user facilities have been introduced as the capability of saving and restoring a researcher customized network layout or as novel features to facilitate navigation and data projection on the network explorer interface. Responsiveness has been further improved by transferring some functionality to the client side.

中文翻译：

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RPGeNet v2.0：扩展了视网膜疾病基因相互作用网络的范围。

RPGeNet为研究人员提供了一种用户友好的可查询工具，以可视化视觉障碍基因的相互作用组网络，从而能够鉴定出新的潜在致病基因，并将新的候选物分配给特定的视网膜或细胞途径。这与临床应用高度相关，因为视网膜营养不良影响了全世界的1：3000人，而致病基因对于30％的患者仍然未知。RPGeNet是一种完善的交互网络接口，可将其骨架网络限制在遗传性和非综合征性视网膜营养不良的每个已知致病基因之间的最短路径。RPGeNet通过Cytoscape.js Web界面集成了来自STRING，BioGRID和PPaxe的交互信息，以及视网膜特定的表达数据和相关的遗传变异。对于新版本RPGeNet v2.0，数据库引擎已迁移到Neo4j图形数据库管理器，该数据库管理器加快了初始查询的速度，并可以处理整个交互组数据以新方式查询网络。此外，已经引入了用户设施，作为保存和恢复研究人员定制的网络布局的能力，或者作为促进在网络浏览器界面上导航和数据投影的新颖功能。通过将一些功能转移到客户端，响应性得到了进一步的改善。已经引入了用户设施，作为保存和恢复研究人员定制的网络布局的功能，或者作为促进在网络浏览器界面上导航和数据投影的新颖功能。通过将一些功能转移到客户端，响应性得到了进一步的改善。用户设施已被引入，既可以保存和恢复研究人员定制的网络布局的功能，又可以作为新颖的功能来促进在网络浏览器界面上的导航和数据投影。通过将一些功能转移到客户端，响应性得到了进一步改善。