Normal epithelial tissues often put anti-tumorigenic pressure on newly emerged oncogenic cells through cell-cell communications. In Drosophila epithelium, clones of oncogenic cells mutant for evolutionarily conserved apico-basal polarity genes such as scribble (scrib) and discs large (dlg) are actively eliminated when surrounded by normal cells. It has been reported that c-Jun N-terminal kinase (JNK) signaling in polarity-deficient cells is crucial for their cell death. However, the mechanism by which normal epithelial tissues exert anti-tumorigenic effects on polarity-deficient cells had been elusive. Here, I describe our genetic studies in Drosophila epithelium especially focused on the role of surrounding normal epithelial cells in response to the emergence of polarity-deficient cells. Furthermore, I also describe recent studies regarding the mechanism by which polarity-deficient cells are extruded from the tissue, and discuss future perspectives on the study of cell-cell communications in epithelial homeostasis.

中文翻译：

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消除调节果蝇上皮稳态的致癌细胞。

正常的上皮组织通常通过细胞间通讯对新出现的致癌细胞施加抗肿瘤形成的压力。在果蝇上皮中，当被正常细胞包围时，会主动清除进化上保守的apico-基础极性基因（如涂鸦（scrib）和大的椎间盘（dlg））的致癌细胞突变体。据报道，极性缺陷细胞中的c-Jun N-末端激酶（JNK）信号对于其细胞死亡至关重要。但是，正常上皮组织对极性缺陷细胞发挥抗肿瘤作用的机制尚不清楚。在这里，我描述了我们在果蝇上皮细胞中的遗传研究，特别是研究了周围正常上皮细胞对极性缺陷细胞的出现的反应。此外，