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Rewarding and aversive doses of caffeine alter activity but not conditioned place preference induced by ethanol in DBA/2J mice.
Pharmacology Biochemistry and Behavior ( IF 3.6 ) Pub Date : 2019-10-31 , DOI: 10.1016/j.pbb.2019.172799
Alfredo Zuniga 1 , Christopher L Cunningham 1
Affiliation  

Increases in the consumption of ethanol and caffeine have been attributed to increased subjective feelings of intoxication and pleasure from the combination. Previous studies have shown that caffeine can be rewarding at low doses and aversive at high doses, although these findings are at times inconsistent between studies using comparable doses. Similarly, studies investigating the rewarding effects of ethanol and caffeine combinations have yielded mixed results. To address this issue, the present experiments were designed to investigate the rewarding effects of caffeine, as well as of caffeine + ethanol combinations. Male DBA/2J mice were exposed to an unbiased conditioned place preference (CPP) procedure with various doses of caffeine (1, 3, 10, 30 mg/kg) and ethanol (1, 2 g/kg), as well as various conditioning trial durations (5, 30, 60 min). Caffeine dose-dependently increased locomotor activity during conditioning, and produced a biphasic effect on place conditioning. Specifically, a low dose of caffeine (3 mg/kg) produced place preference, while a high dose (30 mg/kg) produced place aversion. When combined with alcohol, caffeine dose-dependently increased ethanol's stimulatory effect. However, the addition of caffeine had no effect on ethanol place preference, as there were no differences in the strength of place preference between mice conditioned with ethanol alone, and mice conditioned with any combination of ethanol and caffeine. These studies add evidence for caffeine's biphasic effects while also emphasizing the importance of considering temporal and methodological parameters when using Pavlovian conditioning procedures to study drug combinations.



中文翻译:

在 DBA/2J 小鼠中,奖励和厌恶剂量的咖啡因会改变活动,但不会改变乙醇诱导的条件性位置偏爱。

乙醇和咖啡因消耗量的增加归因于组合带来的醉酒和愉悦的主观感觉增加。以前的研究表明,咖啡因在低剂量时可能是有益的,而在高剂量时可能令人厌恶,尽管这些发现有时在使用可比剂量的研究之间不一致。同样,调查乙醇和咖啡因组合的有益效果的研究产生了不同的结果。为了解决这个问题,本实验旨在研究咖啡因以及咖啡因 + 乙醇组合的有益效果。雄性 DBA/2J 小鼠暴露于无偏见的条件性位置偏爱 (CPP) 程序,其中包含各种剂量的咖啡因(1、3、10、30 mg/kg)和乙醇(1、2 g/kg),以及各种条件反射试用时间(5、30、60 分钟)。咖啡因剂量依赖性地增加调节过程中的运动活动,并对位置调节产生双相效应。具体来说,低剂量的咖啡因 (3 mg/kg) 会产生位置偏好,而高剂量 (30 mg/kg) 会产生位置厌恶。当与酒精结合时,咖啡因剂量依赖性地增加乙醇的刺激作用。然而,添加咖啡因对乙醇的位置偏好没有影响,因为单独用乙醇调节的小鼠与用乙醇和咖啡因的任何组合调节的小鼠之间的位置偏好强度没有差异。这些研究为咖啡因的双相效应提供了证据,同时也强调了在使用巴甫洛夫调节程序研究药物组合时考虑时间和方法参数的重要性。

更新日期:2019-10-31
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