Bacterial resistance has been listed as one of the main threats to human health, leading to high mortality rates. Among the mechanisms involved in bacterial resistance proliferation and selection, we can cite cross-resistance, which occurs when resistance events to one anti-infective agent trigger resistance to other agents. Thus, considering the importance of cross-resistance evolution worldwide in the context of resistant bacterial infections, this minireview focused on the description of bacterial adaptation, including biofilm formation. Here, we explored the correlation between different anti-infective agents, including antibiotics, metal ions, biocides, and antimicrobial peptides in bacterial cross-resistance, also highlighting the most reported mechanisms of adaptation that accompany this resistance.

中文翻译：

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细菌对抗感染化合物的交叉耐药性。这是一个真正的问题吗？

细菌抵抗已被列为对人类健康的主要威胁之一，导致高死亡率。在涉及细菌耐药性增殖和选择的机制中，我们可以列举交叉耐药性，这种交叉耐药性是在对一种抗感染剂的耐药事件触发对其他试剂的耐药性时发生的。因此，考虑到在耐药细菌感染的情况下全球交叉耐药进化的重要性，本篇综述着重介绍了细菌适应性的描述，包括生物膜的形成。在这里，我们探讨了细菌交叉耐药性中不同抗感染剂（包括抗生素，金属离子，杀生物剂和抗菌肽）之间的相关性，同时强调了伴随这种耐药性出现的报道最多的适应机制。