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Can the effects of environmental enrichment modulate BDNF expression in hippocampal plasticity? A systematic review of animal studies.
SYNAPSE ( IF 2.3 ) Pub Date : 2019-05-17 , DOI: 10.1002/syn.22103
Waleska Barros 1, 2 , Mirian David 1 , Ana Souza 3 , Mariluce Silva 3 , Rhowena Matos 1, 4
Affiliation  

BACKGROUND AND AIM Environmental enrichment (EE) can be related to changes in the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus of adult rodents. Exposure to EE may also induce neurogenesis in the dentate gyrus (DG). The aim of this systematic review was to analyze the current literature on the correlation between neurogenesis and BDNF expression in the hippocampal DG region resulting from exposure to EE, which is associated with changes in memory, in rodents. METHODS Bibliographic searches of the Medline/PubMed and ScienceDirect databases were carried out, and 334 studies were found. A predefined protocol was used and registered on PROSPERO, and 32 studies were included for qualitative synthesis. The PRISMA was used to report this systematic review. RESULTS Most of the included studies showed that there is little evidence in the literature demonstrating that memory changes resulting from EE are dependent on BDNF expression and that there is an induction of neurogenesis in the hippocampal DG. However, the observed increase in molecular expression levels and cell proliferation is dependent on the age, the timing and duration of exposure to EE. Regarding the methodological quality of the studies, the majority presented a risk of bias due to the high variability in the age of the animals. CONCLUSION There are few studies in the literature that correlate the molecular and cellular mechanisms involved in neurogenesis in the hippocampal DG with BDNF expression in this region in rodents exposed to EE; however, there are other factors that can modulate this neurogenesis.

中文翻译:

环境富集的作用能否调节海马可塑性中的BDNF表达?对动物研究的系统评价。

背景与目的环境富集(EE)可能与成年啮齿动物海马中脑源性神经营养因子(BDNF)表达的变化有关。暴露于EE也可能诱导齿状回(DG)中的神经发生。本系统综述的目的是分析啮齿类动物因暴露于EE导致的海马DG区神经发生与BDNF表达之间的相关性的现有文献。方法对Medline / PubMed和ScienceDirect数据库进行书目搜索,发现334项研究。使用了预定义的方案并在PROSPERO上进行了注册,其中包括32项研究以进行定性合成。PRISMA用于报告该系统评价。结果大多数纳入的研究表明,文献中几乎没有证据表明由EE引起的记忆改变取决于BDNF表达,并且在海马DG中诱导了神经发生。然而,观察到的分子表达水平和细胞增殖的增加取决于暴露于EE的年龄,时间和持续时间。关于研究的方法学质量,由于动物年龄的高度变异性,大多数人存在偏倚的风险。结论文献中很少有研究将与暴露于EE的啮齿动物的海马DG神经发生有关的分子和细胞机制与该区域的BDNF表达相关。但是,还有其他因素可以调节这种神经发生。
更新日期:2019-11-01
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