BACKGROUND This study analyzes colonization of the neonates in a NICU and incidence of these colonized infants developing infections due to the colonizers. METHODS Over a 12 month period, samples (surface swabs and rectal swabs) were obtained from all the infants admitted to NICU. The samples were cultured and examined for the presence of colonizers and especially for multi-drug resistant organisms. RESULTS From the total 533 patients, 473 (89%) neonates acquired colonizers and 60 (11%) did not. Of the 473 (89%) colonized infants, 57 (12%) developed infections of whom 33 (58%) were infected from the same organism as the colonizer and 24 (42%) neonates developed an infection that was different from the colonizer. 416 (88%) infants did not develop any infection inspite of being colonized. CONCLUSIONS The total numbers of babies contracting infection were more in the colonized group than the non-colonized. Other factors like gestational age and preterm may have played a role in development of infection in addition to colonization in these babies. Screening for the presence of MDRO colonization may be of limited use in predicting infections in the colonized individual. However, knowledge of their presence results in implementation of strict infection control practices. This along with judicious uses of antimicrobials effectively reduces infections from colonized bacteria and more importantly prevent their spread.

中文翻译：

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新生儿重症监护病房的表面定殖和随后发生的多种耐药菌感染。

背景技术本研究分析新生儿在新生儿重症监护病房（NICU）的定植以及这些定植的婴儿因定植者引起感染的发生率。方法在12个月的时间内，从所有入住重症监护病房（NICU）的婴儿中获取了样本（表面拭子和直肠拭子）。培养样品并检查是否存在定植剂，尤其是耐多药生物。结果在总共533例患者中，有473例（89％）新生儿获得了定植者，而60例（11％）未获得定居者。在473名（占89％）定植婴儿中，有57名（占12％）发生了感染，其中33名（占58％）与定植者来自同一生物，而24名（42％）新生儿发生了与定植者不同的感染。尽管有定植，但仍有416名（88％）婴儿未发生任何感染。结论殖民地组感染感染的婴儿人数多于非殖民地组。除了这些婴儿的定植，其他因素如胎龄和早产也可能在感染的发展中起作用。筛选MDRO菌落的存在可能在预测被菌落个体中的感染方面用途有限。但是，了解它们的存在会导致实施严格的感染控制措施。结合明智地使用抗菌药物，可有效减少定植细菌的感染，更重要的是防止其传播。筛选MDRO菌落的存在可能在预测被菌落个体中的感染方面用途有限。但是，了解它们的存在会导致实施严格的感染控制措施。结合明智地使用抗菌药物，可有效减少定植细菌的感染，更重要的是防止其传播。筛选MDRO菌落的存在可能在预测被菌落个体中的感染方面用途有限。但是，了解它们的存在会导致实施严格的感染控制措施。结合明智地使用抗菌药物，可有效减少定植细菌的感染，更重要的是防止其传播。