We developed a clinical ophthalmic prototype by combining bimorph deformable mirror (DM)-based adaptive optics (AO) with a confocal scanning laser ophthalmoscope. A low-cost bimorph DM with a large stroke of 50    μ m and an aperture of 20 mm was utilized to realize a strategy for successive AO control of aberration correction, which permitted open-loop compensation for low-order aberrations and closed-loop correction of high-order aberrations to acceptable root mean square errors of < 0.08    μ m in all subjects. Spherical mirrors were folded in a nonplanar configuration to minimize off-axis aberrations and provide a compact, cost-effective design, which achieved a diffraction-limited performance capable of imaging individual photoreceptor cells and blood vessels not only in healthy subjects but also in patients suffering from retinitis pigmentosa. The adaptive optics scanning laser ophthalmoscope (AOSLO) images of the diseased retina had much higher resolutions than those captured by the commercial AO fundus camera, and loss of the photoreceptor mosaic could be distinguished more accurately due to the improvement in resolution. The compact design and easy handling of the bimorph DM-based AO control may facilitate the translation of AOSLO into clinical settings, and this prototype development will continue with future device refinement and extensive clinical testing.

中文翻译：

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基于Bimorph变形镜的自适应光学扫描激光检眼镜，用于临床设计和性能。

我们通过将基于双压电晶片可变形镜（DM）的自适应光学（AO）与共焦扫描激光检眼镜结合起来，开发了一种临床眼科原型。低成本，大行程50μm，孔径20 mm的双压电晶片DM用于实现连续AO控制像差校正的策略，该策略允许对低阶像差进行开环补偿和闭环校正高阶像差在所有受试者中均可接受的均方根误差<0.08μm。球面镜以非平面配置折叠，以最大程度地减少轴外像差，并提供紧凑，经济高效的设计，不仅在健康受试者中而且在色素性视网膜炎患者中均获得了能够对单个感光细胞和血管成像的衍射极限性能。病变视网膜的自适应光学扫描激光检眼镜（AOSLO）图像具有比商用AO眼底照相机捕获的分辨率更高的分辨率，并且由于分辨率的提高，可以更准确地识别出感光体马赛克的丢失。基于双晶DM的AO控件的紧凑设计和易于处理，可能有助于将AOSLO转换为临床设置，并且随着未来设备的完善和广泛的临床测试，该原型开发将继续。病变视网膜的自适应光学扫描激光检眼镜（AOSLO）图像具有比商用AO眼底照相机捕获的分辨率更高的分辨率，并且由于分辨率的提高，可以更准确地识别出感光体马赛克的丢失。基于双晶DM的AO控件的紧凑设计和易于处理，可能有助于将AOSLO转换为临床设置，并且随着未来设备的完善和广泛的临床测试，该原型开发将继续。病变视网膜的自适应光学扫描激光检眼镜（AOSLO）图像具有比商用AO眼底照相机捕获的分辨率更高的分辨率，并且由于分辨率的提高，可以更准确地识别出感光体马赛克的丢失。基于双晶DM的AO控件的紧凑设计和易于处理，可能有助于将AOSLO转换为临床设置，并且随着未来设备的完善和广泛的临床测试，该原型开发将继续。